Core B: Pediatric Rheumatology Informatics (Informatics Core)

核心 B：儿科风湿病信息学（信息学核心）

• 批准号: 8727966
• 负责人: DAVID N. GLASS
• 金额: $ 46.94万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-22 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8727966
• 关键词: Academic Medical Centers; Arthritis; Bioinformatics; Biological; Child; Childhood; Clinical; Communities; DNA Microarray Chip; Data; Data Analyses; Development; Disease; Foundations; Funding; Gene Expression; Gene Expression Profiling; Genomics; Hand; Individual; Informatics; Instruction; Machine Learning; Medicine; Methods; Microarray Analysis; Molecular; Outcome; Pediatric Hospitals; Procedures; Protocols documentation; Research; Research Infrastructure; Research Project Grants; Resources; Rheumatism; Rheumatology; Statistical Methods; base; biomedical informatics; college; data management; data portal; innovation; insight; programs; ranpirnase; success; tool

The Pediatric Rheumatology Informatics Core is a funded component of a P30 Rheumatic Disease Core Center and a major contributor to the past success of the P01program. This core provides biomedical informatics expertise and infrastructure to the Cincinnati Rheumatic Diseases Core Center Research Base at the Cincinnati Children's Research Foundation of Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine. Because of the continued need for extensive microarray data management and analysis support by the proposed P01program, we are proposing to continue to fund a supplement to the Informatics Core. The purpose of the supplement will be to provide adequate bioinformatics infrastructure, expertise and hands on assistance for specific data management and analysis needs of the 4 P01 projects. The core will provide tailored analysis support to individual projects and perform integrative analyses of all data generated throughout the project. The Core will employ standardized, state- of-the-art protocols for management and analysis of microarray data and develop innovative statistical learning approaches for constructing and validating predictive transcriptional signatures. Altogether, the Core will facilitate the use of optimal data analysis procedures by integrating current relevant methodological, biological and clinical insights. The core will also facilitate the meaningful access to data by the scientific community through the development of new JIA Genomics Data Portal (http://JIAGenomics.org), and provide biostatistical support to research projects as needed. The three aims of the core are: 1) To provide research projects with the comprehensive Bioinformatics support for management, analysis and interpretation of DNA microarray data; 2) To develop the JIA genomics data portal (http://JlAGenomics.org) as the community resource for meaningful access to genomics data produced by P01 projects, and to provide the genomics data "context" for meaningful interpretation and analysis of this data; and 3) To apply innovative statistical methods for integrated analysis of JIA genomics data to facilitate the use of mechanistic insights in constructing predictive transcriptional signatures.

儿科风湿病学信息学核心是P30风湿病核心中心的资助组成部分，也是P01项目过去成功的主要贡献者。该核心为辛辛那提儿童医院医学中心的辛辛那提儿童研究基金会的辛辛那提风湿病核心中心研究基地和辛辛那提大学医学院提供生物医学信息学专业知识和基础设施。由于P01计划继续需要广泛的微阵列数据管理和分析支持，我们建议继续资助信息学核心的补充。本补充文件的目的是为4个P01项目的具体数据管理和分析需求提供充分的生物信息学基础设施、专业知识和实践援助。该核心将为各个项目提供量身定制的分析支持，并对整个项目产生的所有数据进行综合分析。核心将采用标准化的、最先进的方案来管理和分析微阵列数据，并开发创新的统计学习方法来构建和验证预测性转录签名。总而言之，核心将通过整合当前相关的方法学、生物学和临床见解，促进最佳数据分析程序的使用。该核心还将通过开发新的JIA基因组学数据门户（http：//www.example.com）促进科学界对数据的有意义的访问，并根据需要为研究项目提供生物统计支持。JIAGenomics.org核心的三个目标是：1）为研究项目提供全面的生物信息学支持，用于管理、分析和解释DNA微阵列数据; 2）开发JIA基因组学数据门户网站（http：JlAGenomics.org），作为有意义地访问P01项目产生的基因组学数据的社区资源，并为这些数据的有意义的解释和分析提供基因组学数据“上下文”;以及3）应用创新的统计方法对JIA基因组学数据进行综合分析，以促进在构建预测性转录签名中使用机械见解。