HLA/KIR Region Genetics in Pediatric Arthritis
HLA/KIR Region Genetics in Pediatric Arthritis
批准号:
7125044
负责人:
DAVID N. GLASS
金额:
$43.91万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-09-30 至 2010-03-31
关键词:
adolescence (12-20)cell surface receptorschild (0-11)clinical researchcooperative studyfamily geneticsgene expressiongenetic mappinggenetic susceptibilityhigh throughput technologyhuman genetic material taghuman subjectjuvenile rheumatoid arthritismajor histocompatibility complexnatural killer cellssingle nucleotide polymorphism
中文摘要
JRA(也称为JIA)包括儿童期最常见的慢性自身免疫性关节病。MHC与风险、易感性或保护有关,以一种特定亚型的方式存在强烈的性别偏见和种族差异。已经显示出多种MHC效应,特别是在最常见的亚型中,即所谓的早发性少关节性JRA (JIA术语中的持续性Oligo),其中三个或更多MHC区域被认为在产生易感性方面相互作用。与其他形式的自身免疫性疾病不同,该病的另一个特征是相对缺乏共同延伸或祖先
英文摘要
JRA (also known as JIA) includes the commonest chronic autoimmune arthropathies of childhood. The MHC is involved with respect to risk, either susceptibility or protection in a subtype specific manner with strong gender bias' and differences between ethnicities. Multiple MHC effects have been shown, especially in the commonest subtype, so called early onset pauciarticular JRA (Persistent Oligo in the JIA terminology) with three or more MHC regions believed to interact in generating susceptibility. An additional feature of the disease, unlike some other forms of autoimmunity, is the relative absence of common extended or ancestral
haplotypes, especially those carrying HLA-DR4 and HLA-DR7 both of which are protective. The three regions include a class I region, or an area telomeric to it, and two class II regions those around HLA DR/DQ and HLA-DP. None of the regions involved are well defined nor were the specific genes involved identified. The alleles marking these regions (HLA-DR8, 11 and HLA-DPB1*0201) are atypical for autoimmunity. This is therefore an unusual MHC contribution to autoimmunity, the elucidation of which lends itself to high throughput technologies. The genetic features, although involving arthritis, are quite distinct from adult rheumatoid arthritis except for about 5% of older children. It is proposed to construct high throughput SNP maps in a family based study. Subtypes have different MHC profiles and in the rarest and most severe form of disease, systemic onset JRA, the MHC effect is rather minimal. In this form, preliminary
data involving KIR gene haplotypes is available. Pursuing these KIR gene observations is proposed. The ability to leverage ongoing pheontyping and family based sample collection ensures a large and continuously growing pool of available DMAs for this project. Some of the patients will also have extensive gene expression studies allowing a comprehensive approach to the MHC and KIR genes in JRA and its subtypes.
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HLA/KIR Region Genetics in Pediatric Arthritis
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批准号:8079360
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项目类别:
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资助金额:$27.16万
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财政年份:2010
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负责人:DAVID N. GLASS
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依托单位:
HLA/KIR Region Genetics in Pediatric Arthritis
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批准号:7870780
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项目类别:
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资助金额:$30.51万
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财政年份:2009
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负责人:DAVID N. GLASS
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HLA/KIR Region Genetics in Pediatric Arthritis
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批准号:7236027
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项目类别:
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资助金额:$40.62万
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财政年份:2005
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负责人:DAVID N. GLASS
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依托单位:
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批准号:7393220
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项目类别:
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资助金额:$40.03万
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HLA/KIR Region Genetics in Pediatric Arthritis
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批准号:7008022
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资助金额:$21.03万
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财政年份:2005
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负责人:DAVID N. GLASS
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依托单位:
HLA/KIR Region Genetics in Pediatric Arthritis
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批准号:7599532
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项目类别:
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资助金额:$39.67万
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财政年份:2005
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负责人:DAVID N. GLASS
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依托单位:
JRA AS A COMPLEX GENETIC TRAIT
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批准号:7203736
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项目类别:
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资助金额:$1.52万
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财政年份:2004
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负责人:DAVID N. GLASS
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依托单位:
Gene Expression in Pediatric Arthritis
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批准号:6795438
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项目类别:
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资助金额:$141.9万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
Core B: Pediatric Rheumatology Informatics (Informatics Core)
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批准号:8727966
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项目类别:
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资助金额:$46.94万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
Core B: Pediatric Rheumatology Informatics (Informatics Core)
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批准号:8532635
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项目类别:
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资助金额:$30.71万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
Core B: Pediatric Rheumatology Informatics (Informatics Core)
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批准号:8380032
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项目类别:
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资助金额:$26.08万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
Gene Expression in Pediatric Arthritis
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批准号:6686245
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项目类别:
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资助金额:$143.52万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
JRA as a Complex Genetic Trait
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批准号:7044172
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项目类别:
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资助金额:$0.21万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
Gene Expression in Pediatric Arthritis
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批准号:8153261
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项目类别:
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资助金额:$141.97万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
Core B: Pediatric Rheumatology Informatics (Informatics Core)
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批准号:8925670
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项目类别:
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资助金额:$51.18万
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财政年份:2003
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负责人:DAVID N. GLASS
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依托单位:
NIAMS Multidiciplinary Clinical Research Center in Cinc*
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批准号:6924557
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项目类别:
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资助金额:$84.17万
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财政年份:2001
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负责人:DAVID N. GLASS
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依托单位:
NIAMS Multidiciplinary Clinical Research Center in Cinc*
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批准号:6662678
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项目类别:
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资助金额:$87.09万
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财政年份:2001
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负责人:DAVID N. GLASS
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依托单位:
NIAMS Multidiciplinary Clinical Research Center
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批准号:6345811
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项目类别:
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资助金额:$119.92万
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财政年份:2001
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负责人:DAVID N. GLASS
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依托单位:
NIAMS Multidiciplinary Clinical Research Center in Cinc*
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批准号:6770225
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项目类别:
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资助金额:$88.09万
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财政年份:2001
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负责人:DAVID N. GLASS
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依托单位:
NIAMS Multidiciplinary Clinical Research Center in Cinc*
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项目类别:
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资助金额:$83.98万
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财政年份:2001
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负责人:DAVID N. GLASS
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依托单位:
海外基金