SPORE in Lung Cancer

匹兹堡大学癌症研究所(UPCI)建议继续在肺癌方面开展一项专门的卓越研究计划(SPORT)。UPCI型肺癌孢子项目的总体目标是提高肺癌检测、肺癌治疗水平，并识别暴露在烟草中的肺癌高危人群。该项目将包括四个主要的肺癌转化研究项目、三个研究核心、一个行政核心、一个发展研究项目和一个职业发展项目。UPCI型肺癌孢子将使用跨学科的方法，通过与基础、人口和临床科学的合作研究人员开展项目来实现其目标。它的方法也是特定于器官的，所有项目都将测试关于肺癌生物学、易感性、检测、预防或治疗的假设。UPCI孢子将执行这一指令，利用新知识对人类进行干预，并确定在肺癌患者或肺癌高危人群中进行观察的生物学基础，从而在五年内将其发现转化为人类群体。UPCI孢子的长期目标是基于其翻译研究项目的研究结果进行临床试验，这些试验将作为改善被诊断为肺癌的患者预后的基础，并定义将有助于识别无症状肺癌的新的生物学工具。这四个主要项目是：(1)使用生物标记物选择性靶向肺癌的雌激素途径；(2)维生素D对炎症和肺癌风险的调节；(3)匹兹堡肺筛查研究中的肺癌风险预测；(4)肺癌中性粒细胞弹性酶的靶向。这三个研究核心将协助主要研究项目、发展研究项目和职业发展调查人员开展肺癌转化研究。研究核心是临床核心(核心B)、组织和血库核心(核心C)和生物统计学/生物信息学核心(核心D)。行政核心(核心A)将为该计划提供科学和财政监督。加州大学伯克利分校的孢子调查人员将作为一个团队共同努力，以实现该计划的目标，并将与来自其他孢子和癌症中心、NCI项目办公室和其他合作组织的翻译调查人员互动，以改善肺癌患者的预后。

The University of Pittsburgh Cancer Institute (UPCI) proposes to continue to conduct a Specialized Program of Research Excellence (SPORE) in Lung Cancer. The overall goals of the UPCI Lung Cancer SPORE are to improve lung cancer detection, improve lung cancer treatment, and identify tobacco exposed individuals at highest risk for lung cancer, The SPORE program will consist of four major translational Research Projects in lung cancer, three Research Cores, an Administrative Core, a Developmental Research Program, and a Career Development Program. The UPCI Lung Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, population, and clinical science. It is also organ-specific in its approach and all projects will test hypotheses about lung cancer biology, susceptibility, detection, prevention, or treatment. The UPCI SPORE will carry out the directive to translate its findings within five years to human populations by using new knowledge to carry out interventions in humans and to determine the biological basis for observations made in patients with lung cancer, or in individuals at high risk for lung cancer. The long-term goal of the UPCI SPORE is to conduct clinical trials based on research results from its translational research projects that will serve as the basis for improving the outcome of patients diagnosed with lung cancer and to define new biological tools that will be useful in identifying asymptomatic lung cancer. The four main Projects are: (1) Selective Targeting of Estrogen Pathways in Lung Cancer Using Biomarkers; (2) Vitamin D Modulation of Inflammation and Lung Cancer Risk; (3) Lung Cancer Risk Prediction in the Pittsburgh Lung Screening Study (4) Targeting Neutrophil Elastase in Lung Cancer. The three Research Cores will assist the main research Projects, Developmental Research Projects, and Career Development Investigators in carrying out lung cancer translational research. The Research Cores are Clinical Core (Core B), Tissue and Blood Bank Core (Core C), and Biostatistics/Bioinformatics Core (Core D). The Administrative Core (Core A) will provide scientific and fiscal oversight for the program. UPCI SPORE investigators will work together as a team to meet the goals of the program and will also interact with translational investigators from other SPOREs and Cancer Centers, the NCI Program Office, and other co-operative groups to improve outcomes for lung cancer patients.