Expression and function of fatty acid binding proteins in asthmatic airway epithelium

哮喘气道上皮中脂肪酸结合蛋白的表达和功能

• 批准号: nhmrc : 325610
• 负责人: A/Pr Michael Rolph
• 金额: $ 15.1万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/expression-function-fatty-airway-epithelium/96034
• 关键词: Expression; function; fatty; acid; binding

Asthma is an inflammatory disease of the lungs that affects over 10% of all Australians. It ranges in severity from mild to life-threatening. Although a number of drugs are currently available for the treatment of asthma, there are many people whose asthma does not respond very well to treatment. We have recently identified a gene called aP2 that is important in the development of asthma. Drugs targeted against this gene may be very useful in the treatment of asthma. In this project, we aim to understand how aP2 is turned on during asthma, and how it contributes to disease development. This information will be essential for designing optimal strategies for drug targeting of the aP2 pathway in asthma.

哮喘是一种肺部炎症性疾病，影响超过10%的澳大利亚人。其严重程度从轻度到危及生命不等。尽管目前有许多药物可用于治疗哮喘，但仍有许多人的哮喘对治疗反应不佳。我们最近发现了一种叫做aP2的基因，它在哮喘的发展中很重要。针对这种基因的药物可能对治疗哮喘非常有用。在这个项目中，我们的目标是了解aP2在哮喘期间是如何开启的，以及它如何促进疾病的发展。这些信息对于设计哮喘aP2途径药物靶向的最佳策略至关重要。