The role of innate inflammatory responses in viral arthritis

先天炎症反应在病毒性关节炎中的作用

• 批准号: nhmrc : 1012292
• 负责人: A/Pr Michael Rolph
• 金额: $ 52.18万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-innate-inflammatory-viral-arthritis/109648
• 关键词: role; innate; inflammatory; responses; viral

Viruses are known to cause arthritis (HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease and human cell culture models by which to study disease caused by viral infections. This models provide an excellent opportunity to explore the mechanisms of rheumatic disease in a functioning animal and to explore new treatment regimes.

已知病毒会引起关节炎（HIV、肝炎病毒、蚊媒病毒）。病毒性关节炎的症状包括关节疼痛、僵硬和肿胀。疾病的机制知之甚少。我们已经开发了一种新的疾病动物模型和人类细胞培养模型，用于研究病毒感染引起的疾病。该模型提供了一个很好的机会，探索风湿性疾病的机制，在一个功能的动物，并探索新的治疗方案。