Membrane order at T cell activation sites

T 细胞激活位点的膜顺序

• 批准号: nhmrc : 510225
• 负责人: A/Pr Michael Rolph
• 金额: $ 34.65万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/membrane-order-t-activation-sites/77458
• 关键词: Membrane; order; cell; activation; sites

The activation of T lymphocytes is essential part of our immune system to fend off harmful intruders. Our research aims to understand the process of T cell activation, in particular, the contribution of fats. We found that fats create a highly ordered patch at the T cell activation site. We want to understand how lipids and proteins work together to activate T cells, how this ordered regions function in T cell activation and whether dietary lipids alter these patches and thus T cell activation.

T 淋巴细胞的激活是我们免疫系统抵御有害入侵者的重要组成部分。我们的研究旨在了解 T 细胞激活的过程，特别是脂肪的贡献。我们发现脂肪在 T 细胞激活位点形成高度有序的斑块。我们想要了解脂质和蛋白质如何共同作用来激活 T 细胞，这些有序区域如何在 T 细胞激活中发挥作用，以及饮食脂质是否会改变这些斑块，从而改变 T 细胞激活。