Disovery of new airway epithelial genes regulating allergic inflammation

发现调节过敏性炎症的新气道上皮基因

• 批准号: nhmrc : 481363
• 负责人: A/Pr Michael Rolph
• 金额: $ 29.8万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/disovery-new-airway-allergic-inflammation/115400
• 关键词: Disovery; new; airway; epithelial; genes

Asthma is an inflammatory disease of the lungs that affects over 10% of all Australians. A number of drugs are currently available for the treatment of asthma, but there are many people whose asthma does not respond well to treatment. We have identified 2 genes, aP2 and mal1, that may be important in the development of asthma. Drugs targeted against these genes may be useful in the treatment of asthma. In this project, we aim to understand how aP2 and mal1 contribute to disease development.

哮喘是一种肺部炎症性疾病，影响超过10%的澳大利亚人。目前有许多药物可用于治疗哮喘，但有许多人的哮喘对治疗反应不佳。我们已经确定了2个基因，aP2和mal 1，这可能是重要的哮喘的发展。针对这些基因的药物可能有助于治疗哮喘。在这个项目中，我们的目标是了解aP2和mal1如何促进疾病的发展。