The Haplotype Map of the Laboratory Mouse Genome
The Haplotype Map of the Laboratory Mouse Genome
批准号:
6727187
负责人:
Mark Joseph Daly
金额:
$80.93万
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-09-30 至 2006-08-31
中文摘要
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英文摘要
DESCRIPTION: (provided by applicant) We propose to create a genome-wide haplotype map in 47 frequently used inbred lab strains of mice in order to enable efficient positional cloning and genotype-phenotype correlation studies. Recent data has established that the genomes of commonly used inbred lab mice, the primary mammalian model system, are simple mosaics of long segments from a very small number of distinct Mus musculus sub-species. By providing a complete description of ancestral segments of variation in each modern strain, the map will allow the use of phenotype data from many strains and QTL mapping information from all crosses simultaneously in the fine mapping of genes responsible for medically relevant phenotypic differences.
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海外基金