Navajo Bone Health Study

纳瓦霍骨骼健康研究

• 批准号: 7143575
• 负责人: MAUREEN A MURTAUGH
• 金额: $ 60.33万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-17 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7143575
• 关键词: aging; body composition; bone; bone density; calcium; clinical research; health; hip; lifestyle; osteoporosis; sex; ultrasound

DESCRIPTION (provided by applicant): The Navajo Bone Health Study aims to begin surveillance of bone health on the Navajo Nation. These efforts will in time enable the Navajo Nation to plan screening and culturally appropriate education and intervention programs targeted towards the segments of the population who are at greatest risk for fracture or osteoporosis. Specifically, we hypothesize that bone density (total bone mineral density (BMD), and BMD at the hip and lumbar spine) will be different in Navajo American Indians than Caucasians. We will examine this hypothesis by measuring bone mineral density (BMD) using dual energy x-ray absorptiometry (DXA) and heel ultrasound (broadband ultrasound attenuation (BUA) and speed of sound (SOS) as well as stiffness index (SI)) compare distributions and z-scores with those reported for Caucasians in the NHANES III database by age and gender groups. We aim to validate the use of heel ultrasound for bone health screening in Navajo Native Americans and create clinically relevant cutoffs for referral in this population. We will examine the association of reported adult fractures with BMD measures (DXA and BUA) to relate these measures to a relevant public health outcomes. In addition we will examine the association of body size, diet (nutrients relevant to bone formation including calcium, vitamin D, Vitamin A and protein), and lifestyle (physical activity) factors to and BMD in Navajo adults and children over the age of 18. Data will be collected in a cross-sectional design coincident with the Navajo EARTH cohort study. DXA will be measured in 1296 randomly selected Navajo men and women. We will select 112 men and 112 women in four 10 year age groups (30-39,40-49,50-59, and 60 and older) to assure that we can adequately estimate BMD in each of these gender specific age groups separately. Heel ultrasound will be measured in approximately 2500 Navajo men and women and associations with BMD measured using DXA, reported adult fractures, and diet and lifestyle factors will be explored. This study is an important first step in surveillance of bone health of Navajo American Indians and make efficient use of the Navajo EARTH Cohort Study which is currently in the field.

描述（由申请人提供）：纳瓦霍骨健康研究旨在开始对纳瓦霍国家的骨骼健康进行监视。这些努力将及时使纳瓦霍民族能够计划筛查和适当的教育和干预计划，该计划针对人口的细分市场，这些人群面临最大的裂缝或骨质疏松症。具体而言，我们假设纳瓦霍美洲印第安人的骨密度（总骨矿物质密度（BMD）和臀部和腰椎BMD）与高加索人不同。 We will examine this hypothesis by measuring bone mineral density (BMD) using dual energy x-ray absorptiometry (DXA) and heel ultrasound (broadband ultrasound attenuation (BUA) and speed of sound (SOS) as well as stiffness index (SI)) compare distributions and z-scores with those reported for Caucasians in the NHANES III database by age and gender groups.我们旨在验证在纳瓦霍原住民中使用高跟鞋超声检查骨骼健康筛查，并在该人群中创建与临床相关的截止。我们将研究报告的成年骨折与BMD措施（DXA和BUA）的关联，以将其联系起来 采取相关公共卫生结果的措施。此外，我们将研究体型，饮食（饮食（营养与骨骼形成有关），包括钙，维生素D，维生素A和蛋白质）以及18岁以上的纳瓦霍人成年人和儿童的生活方式（身体活动）因素与BMD和BMD。 DXA将在1296个随机选择的Navajo男性和女性中进行测量。我们将在四个10岁年龄段（30-39,40-49,50-59和60岁以上）中选择112名男性和112名女性，以确保我们可以分别对这些性别特定年龄段的每个年龄段中的每个年龄段充分估计BMD。将在大约2500名Navajo男性和女性中测量脚跟超声检查，并与使用DXA测量的BMD相关，并将探索饮食和生活方式因素。这项研究是监视纳瓦霍印第安人骨骼健康的重要第一步，并有效利用目前正在现场的纳瓦霍地球队列研究。