Navajo Bone Health Study

纳瓦霍骨骼健康研究

• 批准号: 7422357
• 负责人: MAUREEN A MURTAUGH
• 金额: $ 53.07万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-17 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7422357
• 关键词: Address; Adult; Age; Alaska Native; Alcohol consumption; American Indians; Body Composition; Body Size; Bone Density; Calcium; Caucasians; Caucasoid Race; Child; Classification; Clinical; Cohort Studies; Cross-Sectional Studies; Data; Data Collection; Databases; Densitometry; Diagnosis; Diet; Dietary Calcium; Dietary Proteins; Educational Curriculum; Educational Intervention; Educational workshop; Elderly; Exercise; Fracture; Funding; Gender; Guidelines; Health; Health Personnel; Health Resources; Health Service Area; Heel; Hip region structure; Intake; Intervention; Knowledge; Life Style; Measurement; Measures; Medical Surveillance; Metabolic; National Health and Nutrition Examination Survey; Native Americans; Navajo; Numbers; Nutrient; Osteogenesis; Osteoporosis; Outcome; Participant; Physical activity; Population; Prevalence; Proteins; Public Health; Range; Rate; Reporting; Research; Research Design; Research Personnel; Risk; Risk Factors; Score; Screening procedure; Speed; Standards of Weights and Measures; Surgeon; Surveys; Time; Ultrasonography; Variant; Vertebral column; Visit; Vitamin A; Vitamin D; Weight-Bearing state; Woman; Women' s Health; Work; age group; attenuation; base; bone; bone health; boys; clinically relevant; cost; cost effectiveness; design; food consumption; girls; indexing; information gathering; instrument; intervention program; men; nutrition; programs; sound; whole body imaging

DESCRIPTION (provided by applicant): The Navajo Bone Health Study aims to begin surveillance of bone health on the Navajo Nation. These efforts will in time enable the Navajo Nation to plan screening and culturally appropriate education and intervention programs targeted towards the segments of the population who are at greatest risk for fracture or osteoporosis. Specifically, we hypothesize that bone density (total bone mineral density (BMD), and BMD at the hip and lumbar spine) will be different in Navajo American Indians than Caucasians. We will examine this hypothesis by measuring bone mineral density (BMD) using dual energy x-ray absorptiometry (DXA) and heel ultrasound (broadband ultrasound attenuation (BUA) and speed of sound (SOS) as well as stiffness index (SI)) compare distributions and z-scores with those reported for Caucasians in the NHANES III database by age and gender groups. We aim to validate the use of heel ultrasound for bone health screening in Navajo Native Americans and create clinically relevant cutoffs for referral in this population. We will examine the association of reported adult fractures with BMD measures (DXA and BUA) to relate these measures to a relevant public health outcomes. In addition we will examine the association of body size, diet (nutrients relevant to bone formation including calcium, vitamin D, Vitamin A and protein), and lifestyle (physical activity) factors to and BMD in Navajo adults and children over the age of 18. Data will be collected in a cross-sectional design coincident with the Navajo EARTH cohort study. DXA will be measured in 1296 randomly selected Navajo men and women. We will select 112 men and 112 women in four 10 year age groups (30-39,40-49,50-59, and 60 and older) to assure that we can adequately estimate BMD in each of these gender specific age groups separately. Heel ultrasound will be measured in approximately 2500 Navajo men and women and associations with BMD measured using DXA, reported adult fractures, and diet and lifestyle factors will be explored. This study is an important first step in surveillance of bone health of Navajo American Indians and make efficient use of the Navajo EARTH Cohort Study which is currently in the field.

描述（由申请人提供）：纳瓦霍骨骼健康研究旨在开始监测纳瓦霍族的骨骼健康。这些努力将使纳瓦霍族能够针对骨折或骨质疏松症风险最大的人群规划筛查和文化上适当的教育和干预计划。具体来说，我们假设纳瓦霍美洲印第安人的骨密度（总骨矿物质密度 (BMD) 以及髋部和腰椎的 BMD）与白种人不同。我们将通过使用双能 X 射线吸收测定法 (DXA) 和足跟超声（宽带超声衰减 (BUA) 和声速 (SOS) 以及刚度指数 (SI)）测量骨矿物质密度 (BMD) 来检验这一假设，并将分布和 z 分数与 NHANES III 数据库中按年龄和性别组报告的白种人的分布和 z 分数进行比较。我们的目标是验证足跟超声在美国纳瓦霍原住民骨骼健康筛查中的应用，并为该人群的转诊建立临床相关的临界值。我们将研究报告的成人骨折与 BMD 测量（DXA 和 BUA）的关联，以将这些联系起来 相关公共卫生结果的措施。此外，我们将研究纳瓦霍成人和 18 岁以上儿童的体型、饮食（与骨形成相关的营养素，包括钙、维生素 D、维生素 A 和蛋白质）和生活方式（体力活动）因素与 BMD 的关系。数据将以与纳瓦霍 EARTH 队列研究一致的横断面设计收集。 DXA 将对随机选择的 1296 名纳瓦霍男性和女性进行测量。我们将在四个 10 岁年龄组（30-39、40-49、50-59 和 60 岁及以上）中选择 112 名男性和 112 名女性，以确保我们能够分别充分估计每个特定性别年龄组的 BMD。将对大约 2500 名纳瓦霍男性和女性进行足跟超声检查，并将探讨与使用 DXA 测量的 BMD、报告的成人骨折以及饮食和生活方式因素的关系。这项研究是监测纳瓦霍美洲印第安人骨骼健康的重要第一步，并有效利用了目前正在进行的纳瓦霍地球队列研究。