Extending life after lung transplantation – Defining the structural and immunological drivers of chronic lung allograft dysfunction

延长肺移植后的生命 — 定义慢性同种异体肺移植功能障碍的结构和免疫驱动因素

• 批准号: nhmrc : 1144826
• 负责人: A/Pr Glen Westall
• 金额: $ 49.98万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/extending-life-lung-allograft-dysfunction/1320289
• 关键词: Extending; life; after; lung; transplantation

Lung Transplantation (LTx) saves life. However, chronic rejection limits survival after LTx compared to other solid organ transplants. Chronic rejection develops when the LTx recipient produces antibodies against the donor lung. With a team of global leaders in the field we will dissect the antibody response to LTx. By better understanding the immune drivers of antibody-mediated rejection, we aim to reduce the incidence of chronic rejection thereby improving survival after LTx.

肺移植（LTx）可以挽救生命。然而，与其他实体器官移植相比，慢性排斥限制了LTx后的存活率。当LTx受体产生针对供体肺的抗体时，就会发生慢性排斥反应。与该领域的全球领导者团队一起，我们将剖析对LTx的抗体反应。通过更好地了解抗体介导的排斥反应的免疫驱动因素，我们的目标是降低慢性排斥反应的发生率，从而提高LTx后的生存率。