Regulation type I and II interferon in CD180 regulated B cells and their role in Lupus pathogenesis

本项目的目的是了解CD180调节的B细胞在狼疮发病机制中的作用。我们假设CD180可能具有抑制B细胞中干扰素信号的功能，即SLE中下调表达可能促进TLR7和/或其他干扰素调节的蛋白表达。要解决这个问题，第一步将是确定I型和II型干扰素刺激对B细胞的影响。接下来，我们将研究CD180和干扰素在B细胞中的相互作用。最后，将对狼疮小鼠模型中CD180阳性和阴性B细胞亚群的差异进行研究。

The aim of this project is to understand how CD180 regulated B cells contribute to pathogenesis in lupus. We hypothesise that CD180 may function to dampen interferon signalling in B cells and that is downregulation in SLE may promote TLR7 and/or other interferon regulated protein expression. To address this the first step will be to characterise the effect of type I and II interferon stimulation in B cells. Next, we will examine the interplay between CD180 and interferon in B cells. Finally, investigation will be carried out into the difference between CD180 positive and negative subpopulations of B cells in lupus murine models.