Regulation type I and II interferon in CD180 regulated B cells and their role in Lupus pathogenesis

CD180调节B细胞中I型和II型干扰素的调节及其在狼疮发病机制中的作用

• 批准号: 2609096
• 金额: --
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2609096
• 关键词: Regulation; type; II; interferon; CD180

The aim of this project is to understand how CD180 regulated B cells contribute to pathogenesis in lupus. We hypothesise that CD180 may function to dampen interferon signalling in B cells and that is downregulation in SLE may promote TLR7 and/or other interferon regulated protein expression. To address this the first step will be to characterise the effect of type I and II interferon stimulation in B cells. Next, we will examine the interplay between CD180 and interferon in B cells. Finally, investigation will be carried out into the difference between CD180 positive and negative subpopulations of B cells in lupus murine models.

该项目的目的是了解如何CD 180调节B细胞有助于狼疮的发病机制。我们假设CD 180可能起到抑制B细胞中干扰素信号传导的作用，并且在SLE中下调可能促进TLR 7和/或其他干扰素调节的蛋白表达。为了解决这个问题，第一步将是验证I型和II型干扰素刺激在B细胞中的作用。接下来，我们将研究B细胞中CD 180和干扰素之间的相互作用。最后，将研究狼疮鼠模型中B细胞的CD 180阳性和阴性亚群之间的差异。