Develop of MRI Techniques for Drug-Abuse Applications

药物滥用应用 MRI 技术的开发

• 批准号: 6987938
• 负责人: Yihong Yang
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6987938
• 关键词: bioimaging /biomedical imaging; drug abuse; functional magnetic resonance imaging; head movements; human subject; technology /technique development

Head motion is a common problem in functional MRI (fMRI) experiments, particularly in studies involving injections of drugs. A voluntary head-motion suppression method using the feedback to subjects on their own head motion information in real time is proposed. A real-time fMRI system was developed on standard MR imaging hardware for this purpose. The feedback of head motion information was simplified as a four-way arrow group changing color from green to red when a composite online head motion index went beyond a pre-specified threshold. The arrow indicators were programmed in E-Prime in order that the feedback of head motion information could be integrated into the commonly used visual verbal N-BACK task. A significant suppression of head motion was obtained consistently on all the subjects while the influence on the performance of task and the interference to brain activation had decreased to a minimal level. This method has been routinely used for quality assurance and reduction of head movement in our fMRI experiments.

头部运动是功能性磁共振成像（fMRI）实验中的常见问题，特别是在涉及药物注射的研究中。提出了一种利用受试者自身头部运动信息的真实的反馈来抑制自主头部运动的方法。为此，在标准MR成像硬件上开发了实时fMRI系统。头部运动信息的反馈被简化为一个四向箭头组，当一个复合在线头部运动指数超过一个预先设定的阈值时，颜色从绿色变为红色。箭头指示器在E-Prime中编程，以便头部运动信息的反馈可以集成到常用的视觉言语N-BACK任务中。所有受试者的头部运动都得到了显著的抑制，而对任务执行的影响和对大脑激活的干扰已降至最低水平。该方法已被常规用于我们的fMRI实验中的质量保证和减少头部运动。