Develop of MRI Techniques for Drug-Abuse Applications

药物滥用应用 MRI 技术的开发

• 批准号: 6987938
• 负责人: Yihong Yang
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6987938
• 关键词: bioimaging /biomedical imaging; drug abuse; functional magnetic resonance imaging; head movements; human subject; technology /technique development

Head motion is a common problem in functional MRI (fMRI) experiments, particularly in studies involving injections of drugs. A voluntary head-motion suppression method using the feedback to subjects on their own head motion information in real time is proposed. A real-time fMRI system was developed on standard MR imaging hardware for this purpose. The feedback of head motion information was simplified as a four-way arrow group changing color from green to red when a composite online head motion index went beyond a pre-specified threshold. The arrow indicators were programmed in E-Prime in order that the feedback of head motion information could be integrated into the commonly used visual verbal N-BACK task. A significant suppression of head motion was obtained consistently on all the subjects while the influence on the performance of task and the interference to brain activation had decreased to a minimal level. This method has been routinely used for quality assurance and reduction of head movement in our fMRI experiments.

头运动是功能性MRI（fMRI）实验的常见问题，特别是在涉及注射药物的研究中。提出了一种使用反馈对受试者的反馈实时对受试者进行反馈的抑制方法。为此，在标准MR成像硬件上开发了实时fMRI系统。当复合在线头运动指数超出预先指定的阈值时，头部运动信息的反馈被简化为四向箭头组从绿色变为红色的颜色。箭头指示器是在电子优势中编程的，以便可以将头部运动信息的反馈集成到常用的视觉言语n-back任务中。对所有受试者的头部运动始终如一地抑制，而对任务执行的影响以及对大脑激活的干扰的影响降低至最小水平。在我们的fMRI实验中，该方法通常用于质量保证和减少头部运动。