课题基金 / 基金详情

Transmembrane Signaling through Voltage-gated Ca Channel

Transmembrane Signaling through Voltage-gated Ca Channel
通过电压门控 Ca 通道的跨膜信号传导
批准号：
7007548
负责人：
Lutz Birnbaumer
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7007548
关键词：
biological signal transductioncalcium channeldihydropyridineselectrophysiologymembrane channelsphosphorylationvoltage /patch clampvoltage gated channel

项目摘要

项目成果

Lutz Birnbaumer的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The importance of a serine at the inner mouth of the channel (end of domain IV S6 segment) was studied. Its mutation to alanine abrogated the ability of the channel to enter into mode 2 gating upon stimulation by activation of PKA or addition of BAY-K8644. The serine (Ser 1517) may be a key regulatory site that determines, in coordination with the previously studied Ser 1142 in the selectivity filter, the responsivenes of the channel to phosphorylation and the dihydropyridine agonist. We are testing the hypothesis that loss of mode 2 gating is due to establshment of an ionic bridge between Ser 1517 and one of two nearby lysines from domain I, thus ?freezing? the channel in mode 1 gating.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
3D RENDITION/QUANTITATIVE ANALYSIS GI2 DEFICIENT MICE
  • 批准号：
    7358258
  • 项目类别：
  • 资助金额：
    $2.05万
  • 财政年份：
    2006
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    DUKE UNIVERSITY
3D RENDITION/QUANTITATIVE ANALYSIS GI2 DEFICIENT MICE
  • 批准号：
    7181529
  • 项目类别：
  • 资助金额：
    $2.13万
  • 财政年份：
    2005
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    DUKE UNIVERSITY
3D RENDITION/QUANTITATIVE ANALYSIS GI2 DEFICIENT MICE
  • 批准号：
    6977825
  • 项目类别：
  • 资助金额：
    $2.8万
  • 财政年份：
    2004
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    DUKE UNIVERSITY
CORE--MOLECULAR PROBES
  • 批准号：
    6594231
  • 项目类别：
  • 资助金额：
    $17.42万
  • 财政年份：
    2002
  • 负责人：
    Lutz Birnbaumer
  • 依托单位：
    BAYLOR COLLEGE OF MEDICINE
海外基金