Extinguishing the fire: inflammasome inhibition

灭火：抑制炎症小体

• 批准号: nhmrc : GNT1141131
• 负责人: A/Pr Kate Schroder
• 金额: $ 47.67万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/extinguishing-fire-inflammasome-inhibition/1348351
• 关键词: Extinguishing; fire; inflammasome; inhibition

During injury or infection, our body’s immune system protects us by launching inflammation. But uncontrolled inflammation drives common diseases such as cancer, diabetes, Alzheimer’s and Parkinson's. This research program will reveal how the body deactivates inflammasomes – protein complexes at the heart of inflammation and disease – so we can design better drugs for treating patients with inflammation-driven disease.

在受伤或感染期间，我们身体的免疫系统通过引发炎症来保护我们。但不受控制的炎症会导致癌症、糖尿病、阿尔茨海默氏症和帕金森氏症等常见疾病。这项研究计划将揭示人体如何使炎症体失活--炎症和疾病的核心蛋白质复合体--这样我们就可以设计出更好的药物来治疗炎症驱动的疾病患者。