Caspase 8 apoptotic signalling induced by the inflammasome

炎症小体诱导的 Caspase 8 凋亡信号

• 批准号: nhmrc : 1050651
• 负责人: A/Pr Kate Schroder
• 金额: $ 40.22万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/caspase-8-apoptotic-induced-inflammasome/112166
• 关键词: Caspase; apoptotic; signalling; induced; inflammasome

The death of cells of our body can be an active and purposeful process. Programmed death occurs in response to infection or as a defence against cancerous changes. If a virally infected cell can die prior to replication of the virus, this will control the infection. We have investigated cell death in response to DNA found in the cytoplasm of cells, which can be an indication of infection. The novel cell death pathway we are characterising is relevant to defence against infection and tumours.

我们身体细胞的死亡可能是一个积极而有目的的过程。程序性死亡是对感染的反应或对癌变的一种防御。如果病毒感染的细胞能够在病毒复制之前死亡，这将控制感染。我们研究了在细胞质中发现的DNA对细胞死亡的反应，这可能是感染的迹象。我们正在描述的新的细胞死亡途径与防御感染和肿瘤有关。