Core D--Skills Development

本申请是关于波士顿儿童医院心脏注册中心的临床研究技能开发核心的申请。自1965年成立以来，该登记处在培训在儿科先天性心脏病方面取得学术成就的个人方面有着良好的记录。例如，该项目的几名高级调查人员曾有机会在心脏登记中轮换，或曾是心脏登记研究员。这一核心的广泛目标是提供一个支持调查人员职业发展的环境。CORE的主要特点包括强调人体心脏解剖和先天性心脏病，强调综合病理生理学方法，以及与SCCOR组件的强烈互动。它的前提是，详细了解人类先天性心脏病的病理将为随后的临床或研究工作提供重要基础。该学院由心脏注册中心的工作人员组成，他们提供经典心脏病理学方面的专业知识，以及使用现代分子和细胞生物学方法研究先天性心脏病的SCCOR调查人员。培训计划的结构旨在为受训人员提供访问心脏登记及其大量资源的机会。学员将参与心脏解剖、咨询病例，广泛使用先天性心脏病收集中的教学标本，利用关于先天性心脏病病理学的系列视频节目，并参加由注册处教员主持的讲座和会议。通过参加临床和研究会议，培训体验得到了进一步加强 在病理、心脏病和外科系以及哈佛医学院校园中的俱乐部和正式研讨会上。受训人员将从SCCOR计划以及全国范围内类似临床计划的所有成员中挑选，重点是识别和招募代表性不足的少数民族。这一核心应该提供有关人类先天性心脏病的基本信息，以增强年轻研究人员的经验。

This application is for a Clinical Research Skills Development Core based in the Cardiac Registry at Children's Hospital, Boston. Since its inception in 1965, the Registry has a strong record of training individuals who have been successful in academic careers in pediatric congenital heart disease. For instance, several of the senior investigators of this program have had a chance to rotate in the Cardiac Registry, or have been Cardiac Registry fellows. The broad objective of this Core is to provide an environment that supports career development of the investigators. The key features of the Core include an emphasis on human cardiac anatomy and congenital heart disease, an emphasis on integrative pathophysiologic approaches, and strong interactions with components of the SCCOR. It is based on the premise that a detailed understanding of the pathology of human congenital heart disease would provide an important foundation for subsequent clinical or investigative work. The faculty consists of the staff of the Cardiac Registry, who provide expertise in classic cardiac pathology, as well as SCCOR investigators using modern molecular and cell biologic approaches to study congenital heart disease. The structure of the training program is designed to provide trainees with access to the Cardiac Registry and its considerable resources. Trainees will participate in cardiac autopsies, consultation cases, and make extensive use of the teaching specimens in the congenital heart collection, utilize the video program series on the pathology of congenital heart disease, and participate in lectures and conferences led by the faculty of the Registry. The training experience is further enhanced by attendance in clinical and research conferences, journal clubs and formal seminars in the Departments of Pathology, Cardiology, and Surgery, as well as in the Harvard Medical School campus. Trainees are to be selected from all members of this SCCOR program, as well as similar clinical programs nationwide, with an emphasis on identifying and recruiting under-represented minorities. This Core should provide basic information about human congenital heart disease that enhances the experience of the young investigators.