Pathobiology of the Developing Cardiovascular System

描述（由申请人提供）： 本申请是为了修订机构NRSA，以支持四个医学博士的培训，医学博士/博士，或博士博士后研究员在发展中的心血管系统的病理生物学的多学科领域的研究生涯。 研究实习生将在一位经验丰富的导师的实验室工作3年。 培训教师由19名研究人员组成，他们具有不同的部门背景，但他们的实验室对心血管系统和最先进方法的技术专长有着既定的兴趣。 这些领域包括发育分子生物学、基因表达和生物信息学、免疫生物学、小鼠模型中的基因靶向、分子生物学、人类心血管疾病的分子遗传学、肌肉分子生物学、组织工程和血管生物学。 选定的导师包括许多具有博士后培训经验的资深科学家。 培训计划的结构旨在促进参与教师之间的互动，并为学员提供访问所有实验室及其大量资源的机会。 受训人员将从全国范围内的研究生和临床项目中挑选，重点是确定那些有潜力成为独立研究者的人。 培训计划的主要组成部分是学员在他们选择的实验室进行独立研究。 导师和二级导师系统将确保强大的培训经验。 该计划的一个独特之处在于，强大的实验室经验与儿童医院心脏登记处的教学培训相结合。该注册表是一个非常宝贵的教学资源，为学生提供了对许多形式的先天性心脏病的新见解。 修订后的方案计划包括招募少数民族的具体步骤，以及负责进行研究的具体方案。 该计划的长期目标是吸引和培养个人在心血管系统的学术生涯。 正如经常发生的情况一样，科学家和临床医生经常相互交叉，从而带来转化研究机会和更好的患者护理。

DESCRIPTION (provided by applicant): This application is for an amended institutional NRSA to support the training of four M.D., M.D./Ph.D., or Ph.D. post-doctoral fellows for research careers in the multi-disciplinary field of the pathobiology of the developing cardiovascular system. Research trainees will spend 3 years in the laboratory of an experienced mentor. The training faculty consist of 19 investigators with different departmental backgrounds but whose laboratories have an established interest in the cardiovascular system and technical expertise in state-of-the-art methodology. These areas include developmental molecular biology, gene expression and bioinformatics, immunobiology, gene targeting in mouse models, molecular biology, molecular genetics of human cardiovascular disease, muscle molecular biology, tissue engineering and vascular biology. The selected mentors include many senior scientists with documented experience in postdoctoral training. The structure of the training program is designed to promote interactions between participating faculty and to provide trainees with access to all the laboratories and their considerable resources. Trainees will be selected from graduate and clinical programs nationwide with an emphasis on identifying those individuals with the potential to become independent investigators. The major component of the training program is independent research carded out by trainees in their laboratories of choice. A system of preceptors and secondary mentors will ensure a strong training experience. A unique feature of the program is that the strong laboratory experience is coupled with didactic training in the Cardiac Registry at Children's Hospital. The Registry is an extremely valuable teaching resource that has provided students with new insights into many forms of congenital heart disease. The amended program plan includes specific steps for minority recruitment, as well as specific programs for responsible conduct of research. The long-term goal of this program is to attract and train individuals for academic careers in the cardiovascular system. As has frequently been the case, scientists and clinicians often cross-fertilize each other, leading to translational research opportunities and better patient care.