Pathobiology of the Developing Cardiovascular System

描述(由申请人提供)： 这份申请是为了支持四名医学博士、医学博士/博士或博士后研究员在发展中的心血管系统的病理生物学的多学科领域的研究生涯的培训。研究实习生将在一位经验丰富的导师的实验室里工作3年。培训人员由19名研究人员组成，他们具有不同的部门背景，但他们的实验室对心血管系统有既定的兴趣，并在最先进的方法学方面拥有技术专长。这些领域包括发育分子生物学、基因表达和生物信息学、免疫生物学、小鼠模型的基因靶向、分子生物学、人类心血管疾病的分子遗传学、肌肉分子生物学、组织工程和血管生物学。选定的导师包括许多资深科学家，他们有博士后培训方面的记录经验。培训计划的结构旨在促进参与培训的教员之间的互动，并为受训人员提供使用所有实验室及其大量资源的机会。受训人员将从全国研究生和临床项目中挑选出来，重点是确定那些有潜力成为独立调查人员的人。培训计划的主要组成部分是学员在自己选择的实验室进行的独立研究。一个由导师和二级导师组成的系统将确保强大的培训经验。该计划的一个独特之处在于，强大的实验室经验与儿童医院心脏登记处的教学培训相结合。该登记处是一项极其宝贵的教学资源，为学生提供了对多种形式的先天性心脏病的新见解。修订后的计划包括招募少数族裔的具体步骤，以及负责进行研究的具体计划。该项目的长期目标是为心血管系统的学术生涯吸引和培训个人。正如经常发生的情况一样，科学家和临床医生经常互换受精，从而带来转化性研究机会和更好的患者护理。

DESCRIPTION (provided by applicant): This application is for an amended institutional NRSA to support the training of four M.D., M.D./Ph.D., or Ph.D. post-doctoral fellows for research careers in the multi-disciplinary field of the pathobiology of the developing cardiovascular system. Research trainees will spend 3 years in the laboratory of an experienced mentor. The training faculty consist of 19 investigators with different departmental backgrounds but whose laboratories have an established interest in the cardiovascular system and technical expertise in state-of-the-art methodology. These areas include developmental molecular biology, gene expression and bioinformatics, immunobiology, gene targeting in mouse models, molecular biology, molecular genetics of human cardiovascular disease, muscle molecular biology, tissue engineering and vascular biology. The selected mentors include many senior scientists with documented experience in postdoctoral training. The structure of the training program is designed to promote interactions between participating faculty and to provide trainees with access to all the laboratories and their considerable resources. Trainees will be selected from graduate and clinical programs nationwide with an emphasis on identifying those individuals with the potential to become independent investigators. The major component of the training program is independent research carded out by trainees in their laboratories of choice. A system of preceptors and secondary mentors will ensure a strong training experience. A unique feature of the program is that the strong laboratory experience is coupled with didactic training in the Cardiac Registry at Children's Hospital. The Registry is an extremely valuable teaching resource that has provided students with new insights into many forms of congenital heart disease. The amended program plan includes specific steps for minority recruitment, as well as specific programs for responsible conduct of research. The long-term goal of this program is to attract and train individuals for academic careers in the cardiovascular system. As has frequently been the case, scientists and clinicians often cross-fertilize each other, leading to translational research opportunities and better patient care.