The SCAN Family: Characterization of ZNF174
SCAN 系列:ZNF174 的表征
基本信息
- 批准号:6836081
- 负责人:
- 金额:$ 23.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-01-01 至 2006-12-31
- 项目状态:已结题
- 来源:
- 关键词:DNA binding proteinantibodybinding sitescell differentiationcomplementary DNAdimergel mobility shift assaygene expressiongene induction /repressiongenetic regulationgenetic regulatory elementliquid chromatography mass spectrometrymolecular cloningplatelet derived growth factorpolymerase chain reactionprotein localizationprotein protein interactionprotein sequenceprotein structure functiontissue /cell culturetranscription factoryeast two hybrid system
项目摘要
DESCRIPTION (provided by applicant): In a search for negative regulators of
growth factor gene expression, our group cloned a new zinc finger transcription
factor, which was designated ZNFI74. Analysis of the open reading frame
revealed two types of conserved elements. The first of these structures were
three consensus Cys2-His2 (C2H2) type zinc fingers, while the second was a
novel extended motif which we designated the SCAN domain. The SCAN domain is a
highly conserved 80 amino acid modular element that is found in a family of
more than 50 human Cys2-His2 (C2H2) zinc finger proteins. Like the leucine
zipper, the SCAN domain appears to control association of SCAN domain
containing proteins into non-covalent, multisubunit complexes and may be the
primary mechanism underlying partner choice in the oligomenzation of these
zinc-finger transcription factors. An attractive possibility is that the domain
generates combinatorial diversity within the SCAN family of proteins.
Heterodimer formation could lead to novel DNA recognition properties or to
different regulatory activities, thus expanding the repertoire of the family.
Only a few of the SCAN family members have been characterized, but the initial
findings suggest that these genes play roles in development and
differentiation. Despite the number of members in this family, remarkably
little is known about the domain itself or the functions of most of the
proteins defined by the domain. To investigate this family, we propose three
specific aims to define ZNF174 and characterize the SCAN domain. Specific Aim
1: To further characterize ZNF174, a founding member of the SCAN family;
Specific Aim 2: To determine the proteins that interact with the ZNF174 SCAN
domain; Specific Aim 3: To further characterize the ability of the ZNF 174 SCAN
domain to inhibit DNA binding. Collectively, these studies should define this
transcription factor and provide mechanistic insights into the large number of
C2H2 type zinc finger proteins defined by the SCAN domain.
描述(由申请人提供):在寻找的负面调节剂
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tucker O Collins其他文献
Tucker O Collins的其他文献
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{{ truncateString('Tucker O Collins', 18)}}的其他基金
NUCLEAR FACTOR KAPPA BETA AND INITIATION OF THE ATHEROSC
核因子 KAPPA Beta 和动脉粥样硬化的引发
- 批准号:
7056678 - 财政年份:2005
- 资助金额:
$ 23.23万 - 项目类别:
Pathobiology of the Developing Cardiovascular System
心血管系统发育的病理学
- 批准号:
7084550 - 财政年份:2005
- 资助金额:
$ 23.23万 - 项目类别:
Pathobiology of the Developing Cardiovascular System
心血管系统发育的病理学
- 批准号:
6845019 - 财政年份:2005
- 资助金额:
$ 23.23万 - 项目类别:
The SCAN Family: Characterization of ZNF174
SCAN 系列:ZNF174 的表征
- 批准号:
6689558 - 财政年份:2002
- 资助金额:
$ 23.23万 - 项目类别:
The SCAN Family: Characterization of ZNF174
SCAN 系列:ZNF174 的表征
- 批准号:
6552994 - 财政年份:2002
- 资助金额:
$ 23.23万 - 项目类别:
The SCAN Family: Characterization of ZNF174
SCAN 系列:ZNF174 的表征
- 批准号:
6640604 - 财政年份:2002
- 资助金额:
$ 23.23万 - 项目类别:
NUCLEAR FACTOR KAPPA BETA AND THE INITIATION OF THE ATHEROSCLEROTIC LESION
核因子 Kappa Beta 与动脉粥样硬化病变的发生
- 批准号:
6477453 - 财政年份:2001
- 资助金额:
$ 23.23万 - 项目类别:
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