Re-Engineering the Clinical Research Enterprise

重新设计临床研究企业

• 批准号: 7058409
• 负责人: GREGORY H REAMAN
• 金额: --
• 依托单位: NATIONAL CHILDHOOD CANCER FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058409
• 关键词: bone marrow transplantation; clinical research; clinical trials; health science research support; informatics; interdisciplinary collaboration; pediatric neoplasm /cancer

The broad, long-term objective is to develop a collaborative effort between two clinical trials networks, the Pediatric Blood and Marrow Transplant Consortium (PBMTC) and the Children's Oncology Group (COG), in order to enhance the availability, safety, and efficacy of Pediatric blood and marrow transplantation performed by the PBMTC and COG, jointly optimize BMT protocol performance by the PBMTC and cancer treatment by the COG, and to advance the science and application of BMT through coordinated development of research concepts and collection of data between the PBMTC, the COG, and related networks in BMT. The specific aims include: 1. To expand COG's clinical trails infrastructure to enable an inter-operable clinical research network in pediatric BMT in conjunction with PBMTC. 2. To evaluate the performance of the infrastructure and inter-network informatics applications to actual inter-group clinical trials. 3. To develop standardized informatics tools that will allow for optimal data sharing of clinical research data from clinical trials between the COG/PBMTC and other networks.

其广泛和长期的目标是在两个临床试验网络，即儿科血液和骨髓移植联合会(PBMTC)和儿童肿瘤学小组(COG)之间开展合作，以提高PBMTC和COG进行的儿科血液和骨髓移植的可用性、安全性和有效性，共同优化PBMTC的骨髓移植方案性能和COG的癌症治疗，并通过PBMTC、COG和BMT相关网络之间的研究理念和数据收集的协调发展，促进骨髓移植的科学和应用。 具体目标包括： 1.扩大COG的临床试验基础设施，使儿科BMT与PBMTC建立可互操作的临床研究网络。 2.评估基础设施和网络间信息学应用在实际组间临床试验中的性能。 3.开发标准化的信息学工具，以实现COG/PBMTC和其他网络之间临床试验数据的最佳共享。