CORE--BRAIN IMAGING CORE

脑成像核心已经被添加到这个项目中，因为在过去的五年里，使用MRI进行脑成像的发展非常惊人。这些图像不仅提供了极好的解剖信息，而且我们现在还可以获得局部代谢信息。这两种类型的信息的组合有可能作为阿尔茨海默病风险和疾病进展的新生物标志物，特别是当与我们在本补助金的前几个周期中确定的其他标志物结合使用时。该检查的非侵入性特征对于前瞻性流行病学研究尤其重要。 在老年人群中进行研究，如本文所述。Core将使用t.5T研究扫描仪，这是哥伦比亚最近开发的神经成像项目的一部分，并应用标准成像程序和技术，根据代谢与脑血容量（CBV）之间的关系测量大脑中的局部基础代谢，CBV将通过钆差异图像确定。我们已经扩展了这项技术，使测量的CBV在海马亚区。将标准解剖图像发送至UC Davis的Charles DeCarli医生进行体积分析（总脑体积、高信号白色物质体积、CSF体积、海马和内嗅皮质体积以及卒中位置和体积）。基础代谢数据将根据当地 CBV根据钆注射前后海马子区域（内嗅皮层、下托、CA 1和齿状回）的差异图像计算。将得到的体积和代谢数据输入Excel文件，并转发至EDMS Core。有五个具体目标： L.从WHICAP队列中获取高质量的解剖和CBV图像。 2.将MRI数据存档到RAID系统和单个受试者光盘上。 3.将解剖图像传输给UC，Davis的Charles DeCarli博士进行体积分析。 4.计算海马和苍白球亚区的CBV。 5.从DeCarli博士的分析和特定目标3的基础代谢估计中收集数据，并将其输入EDMS核心维护的项目数据库。

The Brain Imaging Core has been added to this project because of the extraordinary developments in brain imaging using MRI over the last five years. Not only do the images provided excellent anatomical information but we can now obtain local metabolic information as well. The combination of the two types of information has the potential of serving as new biomarkers of risk and disease progression in Alzheimer's disease, particularly when used in conjunction with the other markers we have identified in previous cycles of this grant. The non-invasive character of the exam is particularly important for prospective epidemiological studies in an elderly population as are proposed here. The Core will be using a t.5T research scanner, part of the recently developed neuroimaging program at Columbia and applying both standard imaging procedures and techniques to measure local basal metabolism in the brain based on the relationship between metabolism and cerebral blood volume (CBV) which will be determined from Gadolinium difference images. We have extended this technique to allow measurement of the CBV in hippocampal subregions. The standard anatomical images will be sent to Dr. Charles DeCarli at UC Davis for volumetric analysis (total cerebral volume, volume of white matter hyperintensities, CSF volume, and volumes of the hippocmnpus and entorhinal cortex and stroke location and volume). The basal metabolic data will be estimated from local CBV calculated from difference images pre and post Gadolinium injection for subregions of the hippocampus (entorhinal cortex, subiculum, CA 1 and the dentate gyrus). The resultant volumetric and metabolic data will be entered into an Excel file and forwarded to EDMS Core. There are five specific aims: l. Acquire high quality anatomic and CBV images from the WHICAP cohort. 2. Archive the MRI data onto a RAID system and individual subject optical disks. 3. Transfer the anatomical images to Dr. Charles DeCarli at UC, Davis for volumetric analysis. 4. Calculate CBV in the subregions of the hippocampus and globus palladus. 5. Collect data from Dr. DeCarli's analysis and the basal metabolic estimates from Specific Aim 3 and input them into the project database maintained by the EDMS Core.