Extrasynaptic GABA-A receptors as novel targets for -Hydroxybutyric acid (GHB)

突触外 GABA-A 受体作为羟基丁酸 (GHB) 的新靶点

• 批准号: nhmrc : 1003619
• 负责人: A/Pr Glenn Hunt
• 金额: $ 35.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/extrasynaptic-gaba-a-acid-ghb/108954
• 关键词: Extrasynaptic; GABA; receptors; novel; targets

GHB (known as Fantasy) is a curious substance. It is a drug of abuse, a therapy and occurs naturally in the brain. GHB targets brain proteins including the enigmatic _GHB receptor� which participates in the therapeutic benefits of GHB. Our research will determine whether the delta-containing GABA-A receptors are the elusive "GHB receptor". Uncovering the identity of the the elusive _GHB receptor� would be a major breakthrough in terms of our understanding of the therapeutic and recreational use of GHB and its action as a brain chemical.

GHB(称为幻觉)是一种奇怪的物质。它是一种滥用药物，是一种治疗方法，在大脑中自然发生。GHb以大脑蛋白质为靶标，包括神秘的GHb受体�，它参与了GHb的治疗益处。我们的研究将确定含有增量的GABA-A受体是否是难以捉摸的“GHB受体”。揭示难以捉摸的GHb受体�的身份将是我们对GHb的治疗和娱乐用途及其作为大脑化学物质的作用的理解的重大突破。