?4-containing GABA-A receptors as targets for ?-hydroxybutyric acid (GHB)

含有 β4 的 GABA-A 受体作为 β-羟基丁酸 (GHB) 的靶标

• 批准号: nhmrc : 1069201
• 负责人: A/Pr Glenn Hunt
• 金额: $ 40.71万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/4-containing-gaba-acid-ghb/455376
• 关键词: containing; GABA; receptors; targets; hydroxybutyric

?-Hydroxybutyric acid (GHB) is an elusive substance. On one hand, it is a prescribed drug to treat narcolepsy, and ameliorate alcohol withdrawal. On the other hand, GHB is the club drug “Fantasy” or “Liquid Ecstasy”, taken by many Australians for its social, sexual and euphoric effects. This proposal will identify GHB targets and provide insight to its mechanism of action.

?-羟丁酸（GHB）是一种难以捉摸的物质。一方面，它是治疗嗜睡症和改善酒精戒断的处方药。另一方面，GHB是俱乐部毒品“幻想”或“液体迷幻剂”，许多澳大利亚人因其社交，性和欣快的效果而服用。该提案将确定伽马--羟丁酸的目标，并深入了解其作用机制。