Mapping MTL Contributions to Declarative Memory

描述（由申请人提供）：记忆研究中的一个中心问题是内侧颞叶（MTL）的组成结构如何差异地有助于获得，保留和检索长期记忆。使用高分辨率的功能磁共振成像和皮质扁平化技术，使这些小的，相邻的结构可能的分化相结合，拟议的研究调查MTL内的功能专业化的假设。拟议的实验具体调查假设的基础上的连接解剖的MTL，无论是在其连接到感觉皮层区域和其内在的层次连接。进入MTL的皮层信息的分离表明，不同的MTL子区域可能保持不同类型的记忆表征，因为每个区域都有一组独特的输入，允许一个独特的模式，支持不同类型的表征能力的感觉会聚和整合。此外，MTL加工的层次性表明，不同层次的结构在陈述性记忆中发挥着不同的作用。首先，我们将测试是否编码响应和随后的记忆预测MTL分区依赖于皮质信息，每个分区接收。其次，我们将研究不同的MTL亚区是如何参与项目和关系记忆的编码和检索。最后，我们将考虑如何MTL子区域有助于收购和使用的合取信息。

DESCRIPTION (provided by applicant): A central question in memory research is how component structures of medial temporal lobe (MTL) differentially contribute to acquisition, retention, and retrieval of long-term memories. Using a combination of high-resolution fMRI and cortical flattening techniques that make differentiation of these small, adjacent structures possible, the proposed research investigates hypotheses regarding functional specialization within MTL. The proposed experiments specifically investigate hypotheses based on the connectional anatomy of MTL, both in terms of its connectivity to sensory cortical regions and its intrinsic hierarchical connectivity. The segregation of cortical information entering MTL suggests that different MTL subregions may maintain different types of memory representations since each region has a unique set of inputs allowing for a distinctive pattern of sensory convergence and integration that support different types of representational capabilities. In addition, the hierarchical nature of processing in MTL suggests that structures at different hierarchical levels play distinct roles in declarative memory. First, we will test whether encoding responses and subsequent memory prediction of MTL subregions depend on cortical information that each subregion receives. Second, we will examine how different MTL subregions are involved in item and relational memory at encoding and retrieval. Finally, we will consider how MTL subregions contribute to acquisition and use of conjunctive information.