V Ganglion activity in awake whisking rodents

清醒啮齿动物中的 V 神经节活动

• 批准号: 7110203
• 负责人: Harris ZEIGLER
• 金额: $ 27.13万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110203
• 关键词: behavior test; brain electrical activity; electrophysiology; ganglions; laboratory rat; mechanoreceptors; neuromuscular system; performance; psychic activity level; psychomotor function; sensorimotor system; touch; trigeminal nerve; vibrissae; wakefulness

DESCRIPTION (provided by applicant): An important goal of neuroscience is to understand sensorimotor integration-how the brain processes sensory input and uses it to control movement. "Active touch" behavior is an experimentally accessible example of sensorimotor integration and "haptic" scanning patterns are among the most complex movements generated by the somato-sensorimotor system. However, we have relatively little information about the functional organization of neural systems mediating active touch in any species. The rodent whisking system is a useful model for the study of active touch because its anatomy and physiology are well characterized. The adaptive control of whisking requires a steady stream of input related to the properties of whisker movements, their onset, trajectory and termination. Electrophysiological data suggests that the ensemble of primary afferent fibers innervating a single vibrissa may encode many of these parameters. However, most of our knowledge of sensory coding in this system comes from studies of neural responses to passive vibrissa displacements in anesthetized animals. Understanding sensory processing in this ubiquitous model system would be advanced by characterizing the discharge properties of first order neurons in awake, behaving animals. We have developed a preparation which facilitates such studies and propose to use it to characterize the mechanisms by which sensory inputs associated with active touch are encoded in first order trigeminal ganglion neurons of rodents.

描述（由申请人提供）：神经科学的一个重要目标是了解感觉运动整合——大脑如何处理感觉输入并利用它来控制运动。 “主动触摸”行为是感觉运动整合的一个可通过实验获得的例子，而“触觉”扫描模式是躯体感觉运动系统产生的最复杂的运动之一。然而，我们对任何物种中介导主动触摸的神经系统的功能组织的信息相对较少。啮齿动物搅拌系统是研究主动触觉的有用模型，因为它的解剖学和生理学特征得到了很好的表征。搅拌的自适应控制需要与胡须运动的特性、其开始、轨迹和终止相关的稳定输入流。电生理学数据表明，支配单个触须的初级传入纤维的集合可能编码许多这些参数。然而，我们对该系统中感觉编码的大部分了解来自对麻醉动物被动触须位移的神经反应的研究。通过表征清醒、行为动物的一级神经元的放电特性，可以促进对这种普遍存在的模型系统中感觉处理的理解。我们开发了一种制剂，可以促进此类研究，并建议用它来表征啮齿动物一级三叉神经节神经元中编码与主动触摸相关的感觉输入的机制。