Stroke Genetics in a Multi-Ethnic Community

多种族社区的中风遗传学

• 批准号: 7116908
• 负责人: LYNDA D LISABETH
• 金额: $ 13.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116908
• 关键词: alleles; cardiovascular disorder epidemiology; clinical research; community; ethnic group; family genetics; family structure /dynamics; genetic susceptibility; human subject; linkage disequilibriums; neurogenetics; nucleic acid quantitation /detection; patient oriented research; stroke

DESCRIPTION (provided by applicant): Ischemic stroke is the third leading cause of death in the US, and the number one cause of adult disability. Environmental risk factors for stroke have been identified, but the genetics of stroke have not been well studied. The National Institute of Neurologic Disorders and Stroke (NINDS) has identified stroke genetics as a research priority. There are few trained experts in stroke epidemiology and fewer who focus on genetics. The proposed research works towards the goals outlined by NINDS for stroke genetics by performing critical investigations leading to future population stroke genetics research in the bi-ethnic community of Nueces County, Texas, as well as developing an individual who will devote her career to the study of stroke and its determinants, including genetics. The candidate is a PhD trained epidemiologist currently working in the field of stroke and is dedicated to a career in stroke research. This application proposes a comprehensive 5-year plan to develop the candidate into an independent stroke researcher, including didactic training, such as attendance in stroke clinics and the emergency department to observe stroke patient treatment, formal coursework in genetics, and hands on training in DNA extraction and screening of genetic markers. The candidate's long-term objective is to become a leader in stroke genetics research by combining skills in epidemiology, biostatistics, and genetics. The University of Michigan has a strong Stroke Program and Department of Human Genetics to assure the candidate's success in these endeavors. The Brain Attack Surveillance in Corpus Christi (BASIC) Project, a population-based stroke surveillance study, will be the data source for the proposed research. Interview data and blood samples from study participants will be used to accomplish the following: Aim 1 - To describe the size and structure of families in Nueces County, Texas, and determine the availability of stroke-free spouses and offspring of stroke cases to serve as controls; Aim 2 - To assess the genetic contribution of stroke in the population of Nueces County, Texas; Aim 3 - To verify the accuracy of stroke cases to report stroke among siblings; Aim 4 - To assess allele frequencies for ancestry informative markers, determine patterns of genetic admixture in Nueces County, Texas, and establish the feasibility of blood collection. The Aims of the proposed research pave the way for comprehensive research to investigate the genetic components of stroke including an exploration of the relationship between ethnic genetic admixture and stroke risk and testing specific hypotheses about stroke susceptibility genes.

描述(申请人提供)：缺血性中风是美国第三大致死原因，也是导致成人残疾的第一大原因。卒中的环境危险因素已被识别，但卒中的遗传学尚未得到很好的研究。国家神经疾病和中风研究所(NINDS)已将中风遗传学确定为研究重点。在中风流行病学方面训练有素的专家很少，专注于遗传学的专家也很少。这项拟议的研究旨在实现NINDS为中风遗传学概述的目标，方法是进行关键调查，从而在德克萨斯州努塞斯县的两个民族社区进行未来的人群中风遗传学研究，并培养一名将致力于中风及其决定因素(包括遗传学)研究的个人。 候选人是一名受过博士培训的流行病学家，目前在中风领域工作，致力于中风研究事业。这项申请提出了一个全面的5年计划，以将候选人发展为一名独立的中风研究人员，包括教学培训，如在中风诊所和急诊科就诊观察中风患者的治疗，遗传学的正式课程，以及DNA提取和遗传标记筛选的动手培训。这位候选人的长期目标是通过结合流行病学、生物统计学和遗传学的技能，成为中风遗传学研究的领导者。密歇根大学有一个强大的中风项目和人类遗传学系，以确保候选人在这些努力中取得成功。 Corpus Christi(BASIC)项目中的脑攻击监测是一项以人群为基础的中风监测研究，将成为拟议研究的数据来源。访谈数据和研究参与者的血液样本将用于实现以下目的：目标1-描述德克萨斯州努塞斯县的家庭规模和结构，并确定无中风病例配偶和中风病例的后代作为对照的可用性；目标2-评估德克萨斯州努塞斯县人口中中风的遗传贡献；目标3-验证中风病例报告兄弟姐妹中中风的准确性；目标4-评估祖先信息标记的等位基因频率，确定德克萨斯州努埃克斯县遗传混合的模式，并建立血液采集的可行性。 这项研究的目的是为全面研究中风的遗传成分铺平道路，包括探索种族遗传混合与中风风险之间的关系，以及测试关于中风易感基因的具体假设。