Brain Attack Surveillance in Corpus Christi (BASIC) Project

描述（由申请人提供）：这是一个非常成功的大脑攻击监测科珀斯克里斯蒂（基本）项目的续期申请。BASIC是唯一一个正在进行的针对墨西哥裔美国人的中风监测项目。墨西哥裔美国人是西班牙裔美国人中最大的一部分，也是美国最大的少数民族。自2000年1月该项目开始以来，我们已经收集了超过4，992名脑血管疾病患者的队列，我们能够跟踪他们的复发性脑血管事件以及死亡率。这为我们提供了巨大的力量来检测与中风生物和社会风险因素的关联，这对墨西哥裔美国人以及更广泛的美国人口很重要。我们已经证明墨西哥裔美国人的中风发病率和复发率增加。墨西哥裔美国人和非西班牙裔白人之间的卒中严重程度和缺血性卒中亚型相似。墨西哥裔美国人中风后的死亡率似乎较低。在接下来的五年里，我们将描绘中风率的趋势，并探索墨西哥裔美国人中风负担增加的潜在原因，以及他们生存率的提高。这一信息对于所有人群减少中风的破坏至关重要。我们将继续进行重要的观察，对社区中风护理的计划提供有用。我们将首次调查墨西哥裔美国人和非西班牙裔白人中风后的功能和认知结果。我们现在还将研究卫生保健质量和药物依从性对卒中结局的作用。我们将收集所有中风患者的血液，用于我们小组和其他人的遗传研究，我们已经在墨西哥的一个类似社区启动了中风监测，这将作为与科珀斯克里斯蒂人口进行比较的重要基础。BASIC是一项非常多产的研究，仅在过去四年中就有超过27篇原创同行评审出版物。事实上，这项研究才刚刚开始提供丰富的流行病学和临床数据，这是必要的，以控制流行的脑血管疾病在墨西哥裔美国人。我们知道，未来五年将使我们能够做出直接有益于干预措施的贡献，以减少所有人群的健康差距，预防中风和改善中风结果。公共卫生相关性：这是对科珀斯克里斯蒂（BASIC）项目的脑攻击监测的竞争性更新。这个非常成功的以社区为基础的中风流行病学项目旨在了解德克萨斯州科珀斯克里斯蒂的墨西哥裔美国人和非西班牙裔白人之间中风的健康差异。这是通过观察流行病学和患者访谈完成的。本研究不包含任何干预措施。

DESCRIPTION (provided by applicant): This is a renewal application for the highly successful Brain Attack Surveillance in Corpus Christi (BASIC) Project. BASIC is the only ongoing stroke surveillance project focusing on Mexican Americans. Mexican Americans are the largest segment of the Hispanic American population, the United States' largest minority group. Since the inception of this project in January 2000, we have assembled a cohort of over 4,992 cerebrovascular disease patients for whom we are able to follow for recurrent cerebrovascular events as well as mortality. This gives us tremendous power to detect associations with biological and social risk factors for stroke, important to Mexican Americans as well as the broader United States population. We have demonstrated increased stroke incidence and recurrence in Mexican Americans. Stroke severity and ischemic stroke subtypes are similar between Mexican Americans and non-Hispanic whites. Mortality following stroke appears to be less in Mexican Americans. In the next five years we are positioned to delineate trends in stroke rates, and to explore the potential reasons for the increased stroke burden in Mexican Americans, as well as their improved survival. This information will be critically important to all populations to reduce the devastation of stroke. We will continue to make important observations useful for planning delivery of stroke care in communities. For the first time we will investigate functional and cognitive outcome following stroke in Mexican Americans and non-Hispanic whites. We will now also study the role of health care quality and medication compliance on stroke outcomes. We will collect blood on all stroke patients useful for genetic studies by our group and others, and we have initiated stroke surveillance in a similar community within Mexico that will serve as a great basis for comparison to the Corpus Christi population. BASIC has been a very prolific study with more than 27 original peer-reviewed publications in the last four years alone. Indeed, this study is just beginning to provide the rich epidemiologic and clinical data that are necessary to control the epidemic of cerebrovascular disease in Mexican Americans. We know that the next five years will allow us to make contributions that will be directly useful for interventions to reduce health disparities, prevent stroke and improve stroke outcomes in all populations. PUBLIC HEALTH RELEVANCE: This is a competitive renewal for the Brain Attack Surveillance in Corpus Christi (BASIC) project. This highly successful community-based stroke epidemiology project seeks to understand the health disparity for stroke among Mexican Americans and non Hispanic whites in Corpus Christi, Texas. This accomplished through observational epidemiology and interviews of patients. No intervention is contained in the study.