Brain Attack Surveillance in Corpus Christi (BASIC) Project

描述(申请人提供)：这是一个非常成功的在语料库克里斯蒂(基本)项目脑攻击监测的续签申请。Basic是唯一一个正在进行的中风监测项目，重点是墨西哥裔美国人。墨西哥裔美国人是拉美裔美国人中最大的一部分，拉美裔美国人是美国最大的少数群体。自2000年1月这个项目开始以来，我们已经收集了4992名脑血管疾病患者的队列，我们能够跟踪他们的复发脑血管事件和死亡率。这给了我们巨大的力量来检测与中风的生物学和社会风险因素的关联，这对墨西哥裔美国人以及更广泛的美国人口来说很重要。我们已经证明，在墨西哥裔美国人中，中风的发病率和复发率增加。在墨西哥裔美国人和非西班牙裔白人中，中风的严重程度和缺血性中风亚型相似。墨西哥裔美国人中风后的死亡率似乎较低。在接下来的五年里，我们将描绘中风发生率的趋势，并探索墨西哥裔美国人中风负担增加的潜在原因，以及他们存活率的提高。这些信息将对所有人群减少中风的破坏至关重要。我们将继续使重要的观察结果对社区卒中护理的规划提供有用。我们将首次调查墨西哥裔美国人和非西班牙裔白人中风后的功能和认知结果。我们现在还将研究医疗质量和药物依从性对中风预后的作用。我们将收集所有中风患者的血液，这对我们团队和其他人的基因研究有用，我们已经在墨西哥境内的一个类似社区启动了中风监测，这将作为与Corpus Christi人口进行比较的重要基础。仅在过去四年里，《基本》杂志就发表了27多份经过同行评审的原创出版物，成果丰硕。事实上，这项研究才刚刚开始提供丰富的流行病学和临床数据，这些数据是控制墨西哥裔美国人脑血管疾病流行所必需的。我们知道，未来五年将使我们能够作出贡献，这将直接有益于减少健康差距、预防中风和改善所有人口的中风结果的干预措施。公共卫生相关性：这是科珀斯克里斯蒂的脑攻击监测(BASIC)项目的一次竞争性更新。这个非常成功的基于社区的中风流行病学项目试图了解德克萨斯州科珀斯克里斯蒂的墨西哥裔美国人和非西班牙裔白人之间中风的健康差距。这是通过观察流行病学和对患者的访谈来实现的。这项研究没有包含任何干预措施。

DESCRIPTION (provided by applicant): This is a renewal application for the highly successful Brain Attack Surveillance in Corpus Christi (BASIC) Project. BASIC is the only ongoing stroke surveillance project focusing on Mexican Americans. Mexican Americans are the largest segment of the Hispanic American population, the United States' largest minority group. Since the inception of this project in January 2000, we have assembled a cohort of over 4,992 cerebrovascular disease patients for whom we are able to follow for recurrent cerebrovascular events as well as mortality. This gives us tremendous power to detect associations with biological and social risk factors for stroke, important to Mexican Americans as well as the broader United States population. We have demonstrated increased stroke incidence and recurrence in Mexican Americans. Stroke severity and ischemic stroke subtypes are similar between Mexican Americans and non-Hispanic whites. Mortality following stroke appears to be less in Mexican Americans. In the next five years we are positioned to delineate trends in stroke rates, and to explore the potential reasons for the increased stroke burden in Mexican Americans, as well as their improved survival. This information will be critically important to all populations to reduce the devastation of stroke. We will continue to make important observations useful for planning delivery of stroke care in communities. For the first time we will investigate functional and cognitive outcome following stroke in Mexican Americans and non-Hispanic whites. We will now also study the role of health care quality and medication compliance on stroke outcomes. We will collect blood on all stroke patients useful for genetic studies by our group and others, and we have initiated stroke surveillance in a similar community within Mexico that will serve as a great basis for comparison to the Corpus Christi population. BASIC has been a very prolific study with more than 27 original peer-reviewed publications in the last four years alone. Indeed, this study is just beginning to provide the rich epidemiologic and clinical data that are necessary to control the epidemic of cerebrovascular disease in Mexican Americans. We know that the next five years will allow us to make contributions that will be directly useful for interventions to reduce health disparities, prevent stroke and improve stroke outcomes in all populations. PUBLIC HEALTH RELEVANCE: This is a competitive renewal for the Brain Attack Surveillance in Corpus Christi (BASIC) project. This highly successful community-based stroke epidemiology project seeks to understand the health disparity for stroke among Mexican Americans and non Hispanic whites in Corpus Christi, Texas. This accomplished through observational epidemiology and interviews of patients. No intervention is contained in the study.