CHD & Anxiety: Prevalence, Relationship

冠心病

• 批准号: 6998965
• 负责人: CHERYL N CARMIN
• 金额: $ 15.97万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998965
• 关键词: anxiety disorders; blood chemistry; blood lipid; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; comorbidity; coronary disorder; depression; heart rate; human subject; interview; longitudinal human study; mental health epidemiology; patient oriented research; psychometrics; psychopathology; quality of life; questionnaires; statistics /biometry; tomography

DESCRIPTION (provided by applicant): The goals of this career development award are designed enable the candidate to develop a program of independent research examining the relationship between anxiety disorders and coronary heart disease (CHD). This study would contribute to the investigator's long-term career goal of examining the relationship between anxiety disorders and medical illness, such as CHD. There is a relatively well-established link between emotional and behavioral variables and the risk for CHD. Despite the comorbidity of anxiety and depressive disorders, the lines of research investigating these conditions and CHD have remained largely independent of one another. Further, despite it being more prevalent than and often pre-dating the onset of depression, less attention has been paid to the relationship between anxiety and CHD. The existing research focusing on anxiety disorders in those at risk for or who have CHD is limited by the use of descriptive, rather than state-of-the-art diagnostic measures of psychopathology. It remains unclear to what extent clinically significant anxiety disorders serve as independent risk factors and may be influential in the development of CHD. In order to address the risk that anxiety disorders pose in CHD prone individuals, the initial phase of this award will allow the investigator to develop background in areas related to the interface between cardiology and psychology including psychosocial epidemiology, biostatistics, psychophysiological assessment, and scanning technology related to CHD. Existing epidemiological databases that assess CHD will be utilized to determine whether anxiety disorders are independently related to the development of CHD. The 2 nd phase of the award will be used to apply the skills acquired in coursework and in analyzing existing data to execute a study comparing a sample of anxiety disordered subjects to a matched control group based on anxiety symptoms (severity, frequency, duration), cardiac calcium as assessed by electron beam tomography, lipid levels, and heart rate variability. The investigator is in the unique position of having access to individuals who are being screened for CHD using EBT as well as having access mentors and collaborators involved in multicenter cardiovascular research (Drs. Lynda Powell, Peter Buttrick, Kiang Liu, George Kondos), psychophysiological research (Dr. Stephen Porges) and who are experienced in the psychopathology and treatment of anxiety disorders (Dr. Richard Heimberg).

描述（由申请人提供）：该职业发展奖的目标旨在使候选人能够开发一个独立的研究项目，研究焦虑症和冠心病（CHD）之间的关系。这项研究将有助于研究者的长期职业目标，检查焦虑症和医疗疾病，如冠心病之间的关系。在情绪和行为变量与冠心病风险之间存在相对明确的联系。尽管焦虑和抑郁障碍并存，但调查这些疾病和CHD的研究路线在很大程度上仍然是相互独立的。此外，尽管它比抑郁症更普遍，而且往往早于抑郁症的发作，但人们对焦虑与冠心病之间的关系关注较少。现有的研究集中在那些有冠心病风险或患有冠心病的焦虑症是有限的使用描述性的，而不是国家的最先进的精神病理学诊断措施。目前尚不清楚临床上显著的焦虑症在多大程度上作为独立的危险因素，并可能影响冠心病的发展。为了解决焦虑症在CHD易感人群中造成的风险，该奖项的初始阶段将允许研究者发展与心脏病学和心理学之间的接口相关领域的背景，包括心理社会流行病学，生物统计学，心理生理学评估和与CHD相关的扫描技术。现有的流行病学数据库，评估冠心病将被用来确定是否焦虑症是独立相关的冠心病的发展。该奖项的第二阶段将用于应用在课程中获得的技能，并分析现有数据，以执行一项研究，将焦虑症受试者的样本与基于焦虑症状（严重程度，频率，持续时间）的匹配对照组进行比较，通过电子束断层扫描评估心脏钙，脂质水平和心率变异性。研究者处于独特的地位，可以接触到正在使用EBT进行CHD筛查的个体，也可以接触到参与多中心心血管研究（Lynda Powell博士、Peter Buttrick博士、Kiang Liu博士、乔治Kondos博士）、心理生理学研究（Stephen Porges博士）以及在精神病理学和焦虑症治疗方面经验丰富的导师和合作者（Richard Heimberg博士）。