MSKCC Vivarium

描述（由申请人提供）：纪念斯隆-凯特琳癌症中心（MSKCC）正在为一项耗资1974万美元的项目寻求1500万美元的联邦支持，以扩大和装备现有的最先进的屏障动物陈列室。由于经济条件的恶化，MSKCC被迫停止了实验室研究大楼的第二期建设，因此急需的动物设施扩建未能完成。这一决定，虽然显然是必要的，以确保中心的财政稳定，留下了MSKCC没有足够的动物空间。这个项目对该中心不断发展的研究事业至关重要，原因有很多。首先，动物模型的开发、表征和使用，特别是小鼠模型，对我们旨在理解和控制癌症的研究工作至关重要。其次，在过去的十年中，由于新的教师招聘和强大的技术的发展，通过操纵小鼠基因组来改变癌基因和肿瘤抑制因子的表达，MSKCC研究人员对小鼠的利用急剧增长。MSKCC现在已经达到了正在进行的研究将受到可用动物空间限制的地步。最后，MSKCC正处于实验室研究项目的重大扩张之中。此次扩展的主要目标是通过招募对转化性癌症研究感兴趣的研究者，包括医师兼科学家，来加强基础科学和临床科学之间的联系。由于这些研究人员显然将广泛使用动物模型，因此MSKCC继续招聘教职员工的关键取决于额外动物空间的发展。该项目需要通过安装地下室和相邻建筑的相关间隙/机械空间来扩展现有的动物馆。高效（净/毛72%）的扩建将提供额外的31个小动物饲养室和13个动物程序实验室。扩建工程完成后，将额外提供23,450个单独通风的老鼠笼，可容纳约100,000只老鼠。还要求拨款购买高密度单独通风笼系统（IVCS）；垂直换流站；生物安全柜；以及专门为安全有效的啮齿动物二氧化碳安乐死而设计的IVCS。所要求的资金将完全用于支持美国的就业。建设和设备采购将创造约2万个工作日。每年需要七千二百五十个工作日的工作人员在满满的情况下工作。可持续设计和施工方法是项目的关键组成部分。MSKCC预计在建筑完工后获得LEED银级认证。

DESCRIPTION (provided by applicant): The Memorial Sloan-Kettering Cancer Center (MSKCC) is seeking $15 M of federal support for a $19.74 M project to expand and equip an existing state-of-the-art barrier vivarium. As a result of weakening economic conditions, MSKCC was forced to cease construction on the second phase of a laboratory research building so a much-needed animal facility expansion was not completed. This decision, although clearly necessary to ensure the Center's financial stability, has left MSKCC with insufficient vivarium space. This project is vital to the center's growing research enterprise for a number of reasons. First, the development, characterization, and use of animal models, particularly mouse models, are critical to our research efforts aimed at understanding and controlling cancer. Second, the utilization of mice by MSKCC researchers has grown dramatically over the last decade, due to new faculty recruitments and the development of powerful technologies for manipulating the mouse genome to alter the expression of oncogenes and tumor suppressors. MSKCC has now reached the point where ongoing research will be limited by the available animal space. Finally, MSKCC is in the midst of a major expansion of its laboratory research programs. The principal goal of this expansion is to strengthen the interface between basic and clinical science by recruiting investigators, including physician-scientists, who are interested in translational cancer research. Since these investigators will clearly make extensive use of animal models, continued faculty recruitment at MSKCC is critically dependent upon the development of additional animal space. The project entails expanding an existing vivarium by fitting out the cellar and associated interstitial/mechanical space of a contiguous building. The highly efficient (72% net/gross) expansion will provide an additional 31 small animal holding rooms and 13 animal procedure laboratories. When complete, the expansion will provide an additional 23,450 individually ventilated mouse cages, with the capacity to house approximately 100,000 mice. Funding is also requested to purchase high density individually ventilated caging systems (IVCS); vertical flow changing stations; biological safety cabinets; and specialized IVCS designed for safe and efficient rodent CO2 euthanasia. The requested funds will be used entirely in support of American jobs. Approximately 20,000 worker days will be created by construction and equipment purchase. Seven thousand two hundred fifty worker days per year will be required to staff the vivarium when fully occupied. Sustainable design and construction methods are key components of the project. MSKCC anticipates obtaining LEED silver certification upon building completion.