Eclipse RD Cyclotron

描述(由申请人提供)： 正电子发射断层扫描(PET)作为核医学和药物研发中的一种强有力的成像技术，伴随着对新的放射性标记方法和适当的放射性核素的需求的增加。用于医疗应用的发射正电子的放射性核素的选择继续要求准确了解核结构和衰变数据。在使用寿命短的放射性核素，即碳-11、氮-13和氧-15时，放射化学家的任务尤其具有挑战性。较短的半衰期严重限制了用于结合特定放射性核素的合成路线和方法，并限制了基于现成的标记前体的那些路线的化学途径。三十多年来，纪念斯隆-凯特琳癌症中心的回旋加速器核心设施在回旋加速器产生的放射性核素和放射性标记化合物的制备和应用方面取得了成功。直到最近，这些考虑在MSKCC尤其重要，其回旋核心设施计划的特点是克服了CS-15回旋加速器施加的能量限制，并制备了适用于早期检测代谢异常的放射性药物化学配方的新型放射性核素。由于研究人员无法控制的情况，最近安装的TR19/9负离子双粒子回旋加速器不得不位于距离主校园几个城市街区的地方，目前它的运营既可生产短期放射性核素，也可生产较长寿命的新型放射性核素。然而，短寿命放射性核素在我们主校区的应用受到了联合体选址的阻碍。行政承诺安装专门的、架子屏蔽的放射性同位素输送系统，专门用于在主园区生产“经典”的短寿命PET放射性核素，消除了许多输送和合成问题，并补充了对更大的TR19/9回旋加速器的生产支持。

DESCRIPTION (provided by applicant): The growth of positron emission tomography (PET) as a powerful imaging technique in nuclear medicine and drug research and development is accompanied by an increasing demand for new radiolabeling methods and appropriate radionuclides. The choice of positron-emitting radionuclides for medical applications continues the requirement for accurate knowledge of nuclear structure and decay data. The radiochemists' task is especially challenging when utilizing the short-lived radionuclides, i.e. carbon-11, nitrogen-13 and oxygen-15. The short half-lives impose serious constraints on the synthetic routes and methods for the incorporation of the specific radionuclide as well as restrict the chemical approaches to those routes based upon readily available labeled precursors. The Cyclotron Core Facility at Memorial Sloan-Kettering Cancer Center has been successful in the preparation and application of cyclotron-produced radionuclides and radiolabeled compounds for more than three decades. Until recently, the considerations were particularly important at MSKCC whose cyclotron core facility program had been characterized by both overcoming the energy constraints imposed by the CS-15 cyclotron and the preparation of novel radionuclides appropriate for radiopharmaceutical chemistry formulations utilized in the early detection of metabolic abnormalities. The recently installed TR 19/9 negative ion, dual particle cyclotron due to circumstances beyond the investigator's control, had to be located several city blocks removed from the main campus and it currently operates for the production of both short-lived and longer-lived novel radionuclides. However, the application of the short-lived radionuclides on our main campus has been hampered by the consortium location site. The administrative commitment for the installation of a dedicated, shelf-shielded, radioisotope delivery system optimized solely to produce the "classical" short lived PET radionuclides on main campus eliminates numerous delivery and synthetic problems and supplements the production support for the larger TR 19/9 cyclotron.