Eclipse RD Cyclotron

Eclipse RD 回旋加速器

• 批准号: 6803890
• 负责人: THOMAS J. KELLY
• 金额: $ 182.5万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803890
• 关键词: biomedical equipment purchase; particle accelerators; positron emission tomography; radiotracer

DESCRIPTION (provided by applicant): The growth of positron emission tomography (PET) as a powerful imaging technique in nuclear medicine and drug research and development is accompanied by an increasing demand for new radiolabeling methods and appropriate radionuclides. The choice of positron-emitting radionuclides for medical applications continues the requirement for accurate knowledge of nuclear structure and decay data. The radiochemists' task is especially challenging when utilizing the short-lived radionuclides, i.e. carbon-11, nitrogen-13 and oxygen-15. The short half-lives impose serious constraints on the synthetic routes and methods for the incorporation of the specific radionuclide as well as restrict the chemical approaches to those routes based upon readily available labeled precursors. The Cyclotron Core Facility at Memorial Sloan-Kettering Cancer Center has been successful in the preparation and application of cyclotron-produced radionuclides and radiolabeled compounds for more than three decades. Until recently, the considerations were particularly important at MSKCC whose cyclotron core facility program had been characterized by both overcoming the energy constraints imposed by the CS-15 cyclotron and the preparation of novel radionuclides appropriate for radiopharmaceutical chemistry formulations utilized in the early detection of metabolic abnormalities. The recently installed TR 19/9 negative ion, dual particle cyclotron due to circumstances beyond the investigator's control, had to be located several city blocks removed from the main campus and it currently operates for the production of both short-lived and longer-lived novel radionuclides. However, the application of the short-lived radionuclides on our main campus has been hampered by the consortium location site. The administrative commitment for the installation of a dedicated, shelf-shielded, radioisotope delivery system optimized solely to produce the "classical" short lived PET radionuclides on main campus eliminates numerous delivery and synthetic problems and supplements the production support for the larger TR 19/9 cyclotron.

描述（由申请人提供）： 正电子发射断层扫描（PET）作为核医学和药物研发中的强大成像技术的增长伴随着对新的放射性标记方法和适当的放射性核素的日益增长的需求。选择正电子发射放射性核素用于医疗用途，仍然需要准确了解核结构和衰变数据。当使用短寿命放射性核素，即碳-11、氮-13和氧-15时，放射化学家的任务尤其具有挑战性。短半衰期对掺入特定放射性核素的合成路线和方法施加了严重的限制，并且限制了基于容易获得的标记前体的那些路线的化学方法。30多年来，纪念斯隆-凯特琳癌症中心的回旋加速器核心设施在回旋加速器产生的放射性核素和放射性标记化合物的制备和应用方面取得了成功。直到最近，这些考虑在MSKCC特别重要，其回旋加速器核心设施计划的特点是克服CS-15回旋加速器施加的能量限制和制备适用于早期检测代谢异常的放射性药物化学制剂的新型放射性核素。最近安装的TR 19/9负离子双粒子回旋加速器由于调查人员无法控制的情况，不得不位于远离主校区的几个城市街区，目前正在生产短寿命和长寿命的新型放射性核素。然而，短寿命放射性核素在我们主校区的应用受到了财团选址的阻碍。行政承诺安装专用的、屏蔽的、放射性同位素输送系统，该系统仅优化用于在主园区生产“经典”短寿命PET放射性核素，消除了许多输送和合成问题，并补充了对更大的TR 19/9回旋加速器的生产支持。