PAR-04-122 Extramural Facilities Construction Grant. "F*

PAR-04-122 校外设施建设补助金。

• 批准号: 7000557
• 负责人: Andrew S Weyrich
• 金额: $ 800万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2014-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000557
• 关键词: Extramural Activities; Facility Construction; Grant

DESCRIPTION (provided by applicant): Advances in medicine depend upon research and technology development at the interfaces of the physical and life sciences. Chemistry is essential to understanding life processes at the molecular level, and new physics-based tools are providing increasingly detailed information about biomolecules and their organization. Most recently, there has been a surge of activity at the biology-chemistry-materials interface (nano-biology) that is promising new drugs, drug delivery systems, diagnostics, and therapeutics. Achieving a predictive understanding of biological systems on every scale (molecules to cells, tissues, organs...) accelerates discovery on each of these frontiers. Predictive understanding only comes with a close union between theory, computation, and experiment. This infrastructure proposal seeks to create a facility that brings together outstanding biological chemistry researchers, both experimentalists and theorists, who are using and advancing computational and physical tools to work at these interfaces. The facility is designed to accommodate a number of individual research groups, and to provide the broader community of NIH researchers with state-of-theart experimental and computational tools. Specifically, the design includes facilities to support: -Mass spectrometry for biomolecular characterization and proteomics; -Optical spectroscopy and chemical imaging of cells, tissue, and single molecules; -X-ray scattering studying biomolecular structures in solution; -Protein biochemistry laboratories for molecular synthesis and reaction mechanism studies; -Theoretical and computational biological chemistry. This powerful set of capabilities, coupled with the Gauss House NMR facilities, will be a cutting-edge interdisciplinary environment for biomedical research in one of the country's leading chemistry departments.

描述（由申请人提供）： 医学的进步取决于物理科学和生命科学之间的研究和技术发展。化学对于在分子水平上理解生命过程至关重要，新的物理学工具正在提供有关生物分子及其组织的越来越详细的信息。最近，生物-化学-材料界面（纳米生物学）的活动激增，这是有前途的新药，药物输送系统，诊断和治疗。实现生物系统的预测性理解的每一个规模（分子细胞，组织，器官.）加速了这些前沿领域的发现。预测性理解只有在理论、计算和实验之间紧密结合的情况下才能实现。 该基础设施提案旨在创建一个设施，汇集优秀的生物化学研究人员，无论是实验学家还是理论家，他们正在使用和推进计算和物理工具在这些接口上工作。该设施旨在容纳一些单独的研究小组，并为更广泛的NIH研究人员提供最先进的实验和计算工具。具体而言，该设计包括支持以下各项的设施： - 用于生物分子表征和蛋白质组学的质谱法; - 细胞、组织和单分子的光谱学和化学成像; - X射线散射研究溶液中的生物分子结构; - 蛋白质生物化学实验室，用于分子合成和反应机理研究; - 理论和计算生物化学。 这套强大的功能，加上高斯楼核磁共振设施，将是一个尖端的跨学科环境，为生物医学研究在该国领先的化学部门之一。