Forsyth Expansion for the Center for Discovery at the Host-Biofilm Interface

福赛斯宿主生物膜界面发现中心扩建

• 批准号: 7841602
• 负责人: PHILIP Stashenko
• 金额: $ 155.75万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-25 至 2013-02-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7841602
• 关键词: Area; Arts; Biological Models; Biology; Cardiovascular Diseases; Clinical; Clinical Research; Core Facility; Diabetes Mellitus; Disease; Employment; Epithelial; Equipment; Funding; Genomics; Grant; Growth; Health; Human; Human Genetics; Human Resources; Immune system; Immunology; Inflammatory Bowel Diseases; Informatics; Institutes; Interdisciplinary Study; Knowledge; Laboratories; Laboratory Technicians; Lead; Leadership; Metabolic syndrome; Microbial Biofilms; Microbiology; Molecular Genetics; Obesity; Occupations; Oral; Oral cavity; Oral health; Postdoctoral Fellow; Premature Birth; Principal Investigator; Proteomics; Recruitment Activity; Request for Applications; Research; Research Institute; Salivary; Scientist; Staging; Surface; Symbiosis; Systemic disease; Systems Biology; Tissues; Translational Research; catalyst; craniofacial; microbial; operation; programs

DESCRIPTION (provided by applicant): The Forsyth Institute, the world's leader in oral and craniofacial disease research, requests $3.79 million to renovate 8,935 ft2 of space for laboratory, core facility, office and clinical research use to create a new interdisciplinary research center of excellence: the Center for Discovery at the Host -Biofilm Interface (CHBI). This project represents a significant expansion of the Institute's research programs, and builds upon Forsyth's internationally-renowned research programs in microbiology/molecular genetics, microbial informatics and immunology. The stage is now set for new paradigm-setting interdisciplinary center that uses the oral cavity as a model system to focus on a critical question: how do humans co-exist with their microbial passengers? The creation of the CHBI will involve the recruitment of 6-8 new principal investigators who will synergize with our existing research strengths, and will generate dramatic new advances in understanding how humans co-exist with their microbial 'passengers' in health, and how perturbations at the host-biofilm interface lead to disease. An aggressive campaign will recruit new scientists in the following areas: human genetics/genomics and proteomics; salivary biology; microbial-epithelial interactions; ontogeny of the immune system; regulatory mechanisms at mucosal surfaces; establishment of commensalism; microbial-mineralized tissue interactions; and clinical/translational research particularly relating to oral-systemic disease interactions in diabetes, metabolic syndrome, obesity, cardiovascular disease, inflammatory bowel diseases, premature birth, and others. The CHBI will be further integrated as appropriate into the newly funded Harvard-wide CTSC ('CATALYST', http:catalyst.harvard.edu), and the Harvard Center for Systems Biology. The funding at Forsyth that will be impacted by this programmatic expansion is: $11,666,314 (40 active projects), and fifty-five (55) pending projects ($17,194,158). To our knowledge, the CHBI will be unique in the field of oral health, and will allow Forsyth to bring its long leadership in this field to a new level. The background to this application is that Forsyth will be relocating its present operation to a new state-of the art facility in the Kendall Square area of Cambridge MA, in early Summer 2010. The Institute will lease space for a minimum of15 years (with two additional 5 year options), thus guaranteeing long term occupancy of renovated space. Because Forsyth's existing program relocation per se will occur independent of ARRA construction grant funding, this application requests support only for renovation of space for program expansion for the creation of the CHBI. This program expansion is 'shovel ready' and must be completed by early Summer 2010. It will involve substantial U.S. job creation. This includes immediate job impact (construction and equipment manufacture, 15-17 U.S. jobs), and substantially more long term sustainable employment: 6-8 principal scientists and approximately 18-24 technical personnel including post-doctoral fellows and laboratory technicians. Accordingly, 39-49 new U.S. jobs will be created should this application be funded.

描述（由申请人提供）：福赛斯研究所，在口腔和颅面疾病研究的世界领导者，要求379万美元，用于实验室，核心设施，办公室和临床研究使用的8,935平方英尺的空间翻新，以创建一个新的跨学科的卓越研究中心：在主机发现中心-生物膜接口（CHBI）。该项目代表了该研究所研究项目的重大扩展，并建立在福赛斯在微生物学/分子遗传学，微生物信息学和免疫学方面的国际知名研究项目之上。现在，新的跨学科中心已经准备好了，该中心将口腔作为一个模型系统，专注于一个关键问题：人类如何与他们的微生物乘客共存？CHBI的创建将涉及招募6-8名新的主要研究人员，他们将与我们现有的研究优势协同作用，并将在理解人类如何与健康的微生物“乘客”共存以及宿主生物膜界面的扰动如何导致疾病方面产生巨大的新进展。 一项积极的运动将在以下领域招募新的科学家：人类遗传学/基因组学和蛋白质组学;唾液生物学;微生物-上皮相互作用;免疫系统的个体发生;粘膜表面的调节机制;粘膜形成;微生物-矿化组织相互作用;和临床/转化研究，特别是与糖尿病、代谢综合征、肥胖症、心血管疾病炎症性肠病、早产和其他疾病。CHBI将进一步整合到新资助的哈佛CTSC（“CATALYST”，http：catalyst.harvard.edu）和哈佛系统生物学中心。福赛斯将受此方案扩展影响的资金为：11，666，314美元（40个活动项目）和五十五（55）个待决项目（17，194，158美元）。据我们所知，CHBI在口腔健康领域将是独一无二的，并将使福赛斯将其在该领域的长期领导地位提高到一个新的水平。 该申请的背景是，福赛斯将于2010年初夏将其目前的业务搬迁到马萨诸塞州剑桥肯德尔广场地区的一个新的最先进的设施。研究所将租用场地至少15年（另有两个5年的选择），从而保证长期使用翻修后的场地。由于福赛斯现有的项目搬迁本身将独立于ARRA建设赠款资金，因此本申请仅要求支持为创建CHBI而进行的项目扩展空间翻新。该计划的扩展是'铲准备'，必须在2010年初夏完成。这将为美国创造大量就业机会。这包括直接的就业影响（建筑和设备制造，15-17个美国就业机会），以及更长期的可持续就业：6-8名首席科学家和大约18-24名技术人员，包括博士后研究员和实验室技术人员。因此，如果这项申请得到资助，美国将创造39-49个新的就业机会。