Mckinly Laboratory Animal Facility Renovation and Expan*

麦金利实验动物设施改造和扩建*

• 批准号: 6950472
• 负责人: CHARLES G. RIORDAN
• 金额: $ 800万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-10 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6950472
• 关键词: Accreditation; Air; Animal Model; Animals; Area; Arts; Basic Science; Cardiovascular system; Delaware; Development; Faculty; Funding; Grant; Growth; Immunocompromised Host; Institutes; International; Laboratories; Laboratory Animals; Malignant Neoplasms; Methodology; Mus; Neurosciences Research; Postdoctoral Fellow; Research; Research Personnel; Research Training; Rodent; Sanitation; System; Transgenic Mice; Transgenic Organisms; United States National Institutes of Health; Universities; animal care; animal facility; beneficiary; career development; design; facility renovation; graduate student; human disease; improved; meetings; member; mouse model; programs; research study

This proposal is to renovate and expand the laboratory animal care facility on the lower level of the McKinly Laboratory at the University of Delaware (UD), including upgrades in sanitation, air handling and support facilities. The long term objectives are to expand UD's capacity for development and utilization of transgenic mouse models of human disease in national priority areas and support the growth of cancer, cardiovascular, and neuroscience research programs. Specific aims are to (1) provide a state of the art mouse barrier unit to support the development and use of transgenic and immunocompromised animal models; (2) provide additional animal holding capacity for genetically modified rodents; (3) replace the existing 30 year old air handling system; (4) expand the sanitation area and introduce a tunnel washer to support animal facility functions; and (5) meet or exceed the facility standards for AAALAC International accreditation. The beneficiaries are UD faculty members in seven different basic science departments which are conducting cutting edge research funded by NIH institutes. The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around limited animal facilities; accelerate the career development of junior investigators; and improve research training opportunities for undergraduates, graduate students, and postdoctoral fellows.

本提案旨在对位于地下一层的实验动物护理设施进行翻新和扩建， 特拉华州大学（UD）的麦金利实验室，包括卫生、空气处理和 支助设施。长期目标是扩大UD的开发和利用能力 在国家优先领域建立人类疾病的转基因小鼠模型，并支持 癌症、心血管和神经科学研究项目。具体目标是：（1）提供一个 支持转基因和免疫受损小鼠的开发和使用 动物模型;（2）为转基因啮齿动物提供额外的动物容纳能力;（3） 更换已有30年历史的空气处理系统;（4）扩大�生区，并在 隧道式清洗机，以支持动物设施的功能;及（5）符合或超过设施标准， AAALAC国际认证。 受益者是七个不同基础科学部门的UD教职员工， 进行由国家卫生研究院资助的前沿研究。这笔赠款将有助于促进 招募更多依赖动物模型的NIH资助的研究人员; 目前NIH资助的研究人员目前必须设计他们的实验和方法 围绕有限的动物设施;加速初级研究人员的职业发展;并提高 为本科生、研究生和博士后研究员提供研究培训机会。