Extramural Research Facilities Improvement Program "Dru*

校外研究设施改进计划“Dru*

• 批准号: 7001006
• 负责人: Harold L. Paz
• 金额: $ 278.63万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-20 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001006
• 关键词: Extramural Activities; programs; research facility

DESCRIPTION (provided by applicant): The objective of this application is to obtain matching funds to integrate and enlarge space for the existing Drug Discovery Core Facility (DDCF) of the Pennsylvania State University College of Medicine (PSUCOM). Drug discovery and development are the natural extension of basic biomedical research, and many faculty members at PSUCOM are conducting research with strong potential for the development of preventative, diagnostic or therapeutic agents. While the DDCF is an established unit and enjoys the ongoing support of PSUCOM administration, the funding requested in this application will provide the resources to: 1. Consolidate and integrate existing and planned shared resources that support drug discovery and development. 2. Meet space requirements for funded investigators, while fostering an institutional identity for the Drug Discovery Program. 3. Create expansion potential for DDCF-related infrastructure. 4. Create contiguous office space to provide dedicated data analysis workstations and to promote collaboration. 5. Create communal space for faculty and student users of the DDCF. 6. Establish laboratory and office space to enhance the training of students, postdoctoral fellows and faculty. 7. Facilitate reporting of discoveries by PSUCOM faculty and promote technology transfer. This application seeks funding to renovate a 6,600 square foot facility on the second floor of the Biomedical Research Building of the PSUCOM, in close proximity to 1,700 square feet of office and collaborative workspace, to support the Drug Discovery Program. Funding this application will have a major positive impact on the translation of basic research to clinical application within the PSUCOM.

描述（由申请人提供）： 本申请的目的是获得配套资金，以整合和扩大宾夕法尼亚州立大学医学院（PSUCOM）现有药物发现核心设施（DDCF）的空间。药物发现和开发是基础生物医学研究的自然延伸，PSUCOM的许多教职员工正在进行具有开发预防，诊断或治疗药物的强大潜力的研究。虽然DDCF是一个既定的单位，并享有PSUCOM管理的持续支持，本申请中要求的资金将提供资源：1。整合和整合现有的和计划的共享资源，以支持药物发现和开发。2.满足受资助研究人员的空间要求，同时为药物发现计划培养机构身份。3.为DDCF相关基础设施创造扩展潜力。4.创建连续的办公空间，以提供专用的数据分析工作站并促进协作。5.为DDCF的教师和学生用户创建公共空间。6.建立实验室和办公场所，以加强对学生、博士后研究员和教师的培训。7.促进PSUCOM教师报告发现并促进技术转让。该申请旨在获得资金，以翻新PSUCOM生物医学研究大楼二楼的6，600平方英尺的设施，靠近1，700平方英尺的办公室和协作工作区，以支持药物发现计划。资助该应用将对PSUCOM内基础研究向临床应用的转化产生重大积极影响。

项目成果

Combined, but not individual, blockade of ASIC3, P2X, and EP4 receptors attenuates the exercise pressor reflex in rats with freely perfused hindlimb muscles.

联合而非单独阻断 ASIC3、P2X 和 EP4 受体会减弱后肢肌肉自由灌注的大鼠的运动升压反射。

• DOI: 10.1152/japplphysiol.00630.2015
• 发表时间: 2015
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Stone,AudreyJ;Copp,StevenW;Kim,JoyceS;Kaufman,MarcP
• 通讯作者: Kaufman,MarcP