Meeting on Inhaled Mineral Dusts/Nanoparticles

描述(由申请人提供)： 本申请申请资助第8届“吸入矿物粉尘和纳米颗粒”国际会议，目的是了解与吸入颗粒和纤维有关的呼吸系统疾病的风险和机制。在历史上，这些疾病包括与职业和环境暴露于石棉、二氧化硅、煤尘和合成纤维/颗粒有关的炎症性、纤维性和致癌性肺和胸膜疾病。最近，公共卫生关注的重点是肺部疾病的恶化，如哮喘和慢性阻塞性肺病，以及与周期性、高暴露于环境颗粒物(PM)有关的心血管疾病。这一系列会议历史上始于20世纪70年代末，在威尔士加的夫的MRC尘肺病中心举行，传统上每4-5年举行一次，地点在欧洲和美国之间改变。会议的总体目标是提供一个论坛，介绍和讨论最近的基础和应用研究进展，重点是暴露于纤维/颗粒与可能导致疾病风险增加的宿主因素之间的相互作用。会议将于2005年10月26日至28日在北卡罗来纳州的研究三角公园举行，这里是EPA和NIEHS粒子/纤维疾病实验室的主要所在地。所需资金将用于支付大多数受邀发言者和会议主席、肺部生物学、病理学、生理学、临床医学和流行病学方面的公认专家以及该领域有竞争力的年轻调查人员的旅费和住宿费，他们也将作口头介绍。主要分为5个部分：1)环境颗粒物与人类健康，2)天然和人造纤维暴露与宿主反应机制，3)金属反应机制，4)纳米颗粒：健康影响和应用，5)宿主对二氧化硅、煤尘和其他颗粒的易感性。每个主题的相应海报会议将允许其他研究人员以及初级科学家的投入和参与。结束性讨论将讨论“肺部生物学方面的研究差距是什么？”以及“这对公众健康有什么影响？”会议总结和结论将发表在《环境健康展望》或《美国胸科学会杂志》上。这次会议将提供一个交流研究想法和合作的论坛，以促进公共卫生领域了解个人对颗粒物引起的肺部疾病的易感性和机制。

DESCRIPTION (provided by applicant): This application requests funds for support of the 8th International Meeting on "Inhaled Mineral Dusts and Nanoparticles" with the goals of understanding the risks and mechanisms of respiratory diseases associated with inhaled particles and fibers. These historically have included inflammatory, fibrogenic and carcinogenic lung and pleural diseases associated with occupational and environmental exposures to asbestos, silica, coal dusts and synthetic fibers/particles. More recently, public health concern has focused on the exacerbation of lung diseases such as asthma and COPD as well as cardiovascular disease linked to periodic, high exposures to ambient particulate matter (PM). This series of meetings historically began in the late 1970s at the MRC Pneumoconiosis Center in Cardiff, Wales, and traditionally have been held every 4-5 years, altering in location between Europe and the US. The overall goal of the meeting is to provide a forum for presentation and discussion of recent basic and applied research progress with an emphasis on interactions between exposures to fibers/particles with host factors that may lead to increase risks of disease. The meeting will be held October 26-28, 2005 in Research Triangle Park, NC, a primary location of EPA and NIEHS laboratories on particle/fiber disease. Funds requested will support the travel and hotel stay for the majority of invited speakers and session chairs, recognized experts in lung biology, pathology, physiology, clinical medicine and epidemiology, as well as competitive young investigators in the field who will also give oral presentations. There are 5 main sessions on : 1) Ambient Particulates and Human Health, 2) Exposure to Natural and Man- Made Fibers and Mechanisms of Host Response, 3) Mechanisms of Response to Metals, 4) Nanoparticles:Health Implications and Applications, and 5) Host Susceptibility to Silica, Coal Dusts and Other Particles. Corresponding poster sessions on each topic will allow input and participation of other investigators, as well as junior scientists. A concluding discussion will address "what are the research gaps in lung biology?" and "what are the implications for public health?" A meeting summary and conclusions will be published in either Environmental Health Perspectives or in American Thoracic Societyjournals. This meeting will provide a forum for exchange of research ideas and collaborations that will advance the field of public health in understanding individual susceptibility to and mechanisms of particulate-induced lung diseases.