2005 Epigenetics Gordon Research Conference

描述（由申请人提供）：表观遗传学的研究涉及基因型产生表型的极其复杂的机制。它适用于几乎所有生物体发育的各个方面，并很好地提醒我们，基因型如何产生表型的本质毕竟并不完全存在于DNA中。本申请请求支持将于2005年8月7日至12日在新罕布什尔州Holderness学校举行的第六届戈登表观遗传学研究会议。邀请的演讲者是研究原核生物、真菌、纤毛虫、植物、蠕虫、昆虫和哺乳动物的顶尖研究人员，他们的演讲将涵盖当今最引人注目和最活跃的科学领域，包括分子和细胞记忆、细胞去分化、DNA不对称、DNA甲基化、RNA干扰、亲代印记、x染色体失活、参数化、倍性、开关、环境压力、基因组防御系统、位置效应、组蛋白修饰、癌症表观遗传学、哺乳动物克隆和干细胞发育。这些主题与人类健康直接相关，因为表观遗传程序的中断是癌症、Prader-Willi综合征和Angelman综合征等印迹基因疾病以及Rett综合征和ICF综合征等精神发育迟滞障碍的基础。

DESCRIPTION (provided by applicant): The study of epigenetics concerns the enormously complex mechanisms by which genotype gives rise to phenotype. It pertains to every aspect of development in virtually all organisms, and has been a good reminder that the essence of how genotype gives rise to phenotype does not, after all, reside completely in DNA. This application requests support for the 6th Gordon Research Conference on Epigenetics to be held at Holderness School, New Hampshire, August 7-12, 2005. Invited speakers are leading researchers working on prokaryotes, fungi, ciliates, plants, worms, insects, and mammals, and their presentations will cover some of the most fascinating and actively-studied areas of science today, including molecular and cellular memory, cellular de-differentiation, DNA asymmetry, DNA methylation, RNA interference, parental imprinting, X-chromosome inactivation, paramutation, ploidy, switching, environmental stress, genome defense systems, position effects, histone modifications, epigenetics of cancer, mammalian cloning, and stem cell development. These topics have direct relevance to human health, since disruptions in epigenetic programs underlie cancer, imprinted gene disorders such as Prader-Willi and Angelman syndromes, and mental retardation disorders such as Rett and ICF syndromes. The 2005 Gordon Research Conference on Epigenetics will provide a unique setting for researchers working on this broad spectrum of mechanisms and organisms to come together and exchange results and ideas. With a limited enrollment, ample time for both formal and informal discussions, and an eye toward promoting the careers of new investigators, the cross-disciplinary environment of this conference will foster the innovative thinking and novel collaborations that are critical for the success of researchers in the field of epigenetics.