Gordon Research Conference on Calcium Signaling

描述（由申请人提供）：资金要求支付部分费用的戈登研究会议钙信号将于2005年7月24日至29日在英国牛津举行。钙是一种普遍存在的细胞内信使;它是许多细胞过程的重要调节剂，包括受精、细胞死亡、感觉转导、肌肉收缩、运动、胞吐和液体分泌。钙信号传导缺陷是多种疾病的一个特征，包括许多造成巨大社会经济负担的疾病（如高血压和免疫缺陷）。会议每两年举行一次（与补充FASEB会议交错），并在欧洲和美国之间交替举行。它为在钙信号的许多方面具有不同兴趣的科学家提供了首要论坛，以回顾这一活跃领域令人兴奋的发展。该方案已被选定，以包括那些最活跃的领域，而不复制最近的GRC或FASEB会议。会议规模小（限于140人，而且总是超额报名），强调互动式讨论，确保了辩论的活跃。有8个会议，与主席选择，以促进积极的讨论，和全体会议。海报是一个关键特征（大多数与会者出席）;他们每天下午都会展示，每个会议主席将选择一张海报（共8张）作为演讲。整个计划的目的是建立参与钙信号传导的蛋白质的结构和功能之间的连续性，以及如何导致对疾病状态的理解。会议致力于钙信号的空间组织，细胞内和质膜钙通道的结构和功能，TRP蛋白在正常和疾病状态中的作用，钙在分泌和血管功能中的作用，以及解码钙信号的会议。这些主题具有根本的重要性，广泛的兴趣和直接相关的许多疾病状态，包括神经退行性疾病和心血管疾病，衰老，癌症，感觉障碍和免疫性疾病。

DESCRIPTION (provided by applicant): Funds are requested to partially cover the costs of the Gordon Research Conference on Calcium Signaling to be held in Oxford, England from 24-29 July 2005. Calcium is a ubiquitous intracellular messenger; it is an essential regulator of many cellular processes including fertilization, cell death, sensory transduction, muscle contraction, motility, exocytosis and fluid secretion. Defective calcium signaling is a feature of diverse diseases, including many (e.g. hypertension and immunodeficiencies) that are huge socioeconomic burdens. The conference takes place biennially (interleaved with the complementary FASEB meeting) and alternates between Europe and the USA. It provides the premier forum for scientists with diverse interests in the many facets of calcium signaling to review exciting developments in this active area. The program has been selected to include those most active in the field without replicating recent GRC or FASEB meetings. The small size of the meeting (limited to 140 and invariably over-subscribed) and emphasis on interactive discussion ensure lively debate. There are 8 sessions, with chairs selected to promote active discussion, and a plenary. Posters are a key feature (most attendees present); they are presented each afternoon and each session chair will select a poster (8 in total) for presentation as a talk. Throughout the program the aim is to establish the continuity between the structure and function of proteins involved in calcium signaling and how that leads to an understanding of disease states. Sessions are devoted to the spatial organization of calcium signaling, the structure and function of intracellular and plasma membrane calcium channels, the roles of TRP proteins in normal and disease states, the roles of calcium in secretion and vascular function, and a session on decoding calcium signals. These topics are of fundamental importance, widespread interest and immediate relevance to many disease states including neurodegenerative and cardiovascular diseases, aging, cancer, sensory disorders, and immunological diseases.