Conference--Systems Biology Methods & Environment Resear

描述（由申请人提供） 系统生物学已经成为一个主要的领域-在基因组学和蛋白质组学的突出和接受的上升之后。 毒理蛋白质组学和毒理基因组学正在成为毒理学家武器库中越来越重要的技术-使我们能够测定环境外源性物质最终对整个基因组或蛋白质组的影响，而不是孤立的基因及其产物。 系统生物学在这一范式中的作用是开发和部署分析使用这些技术生成的大量数据所需的“工具”。 这些工具包括新的生物信息学技术，用于分析这些数据，以确定哪些基因和/或其产物已被环境因子改变，以及建模软件，使我们能够在二氧化硅中进行实验。 在二氧化硅建模将可能有助于了解混合物的毒理学。 本次会议的目的是为正在进行毒理蛋白质组学，毒理基因组学，生物信息学和生物建模环境研究的科学家之间有效交流思想和方法提供一种机制。 该议程的总体计划是强调适用于新的toxicgenomic/toxicoproteomic数据收集的相关环境暴露模型，介绍和讨论使用toxicgenomics和toxicoproteomics的前沿研究，然后介绍最先进的生物信息学计划和技术。 最后，将介绍和讨论最新的生物建模工具。 总计划还要求为每届会议的全体会议分配50分钟的发言时间，其中约10分钟用于提问和讨论。 在全体会议发言之后，将有三个30分钟的发言，每个发言有10分钟的提问时间。 会议结束时将举行由主要发言人/主席主持的小组讨论。 像这样的小型会议的优点是，与大型国家会议形式相比，它们更有利于讨论和交流想法。例如，在一个实施例中，毒理学学会（SOT）。 最后一次会议由商业公司的代表进行介绍，以突出最先进的设备，使毒理学家能够进行环境研究。 我们计划与相关期刊的编辑联系，以找到一个出版本次会议记录的地点，因此，本次会议的赞助者将远远超出会议的参与者，以环境研究人员在世界各地。

DESCRIPTION (provided by applicant) Systems biology has become a major field -coming on the heels of the rise in prominence and acceptance of genomics and proteomics. Toxicoproteomics and toxicogenomics are become increasing important techniques in the arsenal of toxicologists -allowing us to assay the effects of environmental xenobiotics ultimately on the entire genome or proteome instead of isolated genes and their products. The role of systems biology in this paradigm is to develop and deploy the "tools" needed to analyze the vast amounts of data that is generated using these techniques. These tools include new bioinformatic techniques for analyzing these data to determine which genes and/or their products that have been altered by the environmental agents but also modeling software that allow us to conduct experiments in silica. In silica modeling will likely be instrumental in the understanding of the toxicology of mixtures. The purpose of this conference is to provide a mechanism for the effective exchange of ideas and methods between scientists that are conducting toxicoproteomics, toxicogenomics, bioinformatics and biological modeling environmental research. The overall plan for the agenda is to highlight relevant environmental exposure models that are appropriate for new toxicogenomic/toxicoproteomic data collection, presentations and discussion of cutting-edge research using toxicogenomics and toxicoproteomics and then follow this with presentations on state-of-art bioinformatic programs and techniques. Finally, the latest biological modeling tools will be introduced and discussed. The general plan also calls for the allocation of a 50 minute time block for a plenary presentation for each session, reserving approximately 10 minutes of that time for questions and discussion. The plenary presentation will be followed by three 30 minute presentations, each with a 10 minute question time. The session will be concluded with a panel discussion led by the primary speaker/chair. The advantage of smaller meetings, such as this, is that they are more conducive to discussion and exchange of ideas in contrast to larger national meeting formats, e. g., Society of Toxicology (SOT). The final session is reserved for presentations by representatives of commercial companies to highlight state-of-art equipment that will allow toxicologists to perform environmental research. We plan to contact editors of relevant journals to find a venue to publish the proceedings of this conference, thus, the benefactors of this conference will extend far beyond the participants of the conference to environmental researchers worldwide.