Conference--Systems Biology Methods & Environment Resear

描述(由申请人提供) 系统生物学已经成为一个主要领域--紧随其后的是基因组学和蛋白质组学的重要性和接受度的上升。毒物蛋白质组学和毒物基因组学正成为毒物学家日益重要的技术--使我们能够分析环境外源物质最终对整个基因组或蛋白质组的影响，而不是孤立的基因及其产物。系统生物学在这一范例中的作用是开发和部署分析使用这些技术产生的海量数据所需的“工具”。这些工具包括新的生物信息学技术，用于分析这些数据，以确定哪些基因和/或其产品已被环境因素改变，但也包括允许我们在硅石中进行实验的建模软件。在二氧化硅中，建模可能有助于理解混合物的毒理学。 这次会议的目的是为正在进行毒素蛋白质组学、毒素基因组学、生物信息学和生物模拟环境研究的科学家之间有效地交流思想和方法提供一个机制。议程的总体计划是强调适用于新的毒素基因组/毒素蛋白质组数据收集、介绍和使用毒素基因组学和毒素蛋白质组学的前沿研究的相关环境暴露模型，然后介绍最新的生物信息学计划和技术。最后，将对最新的生物建模工具进行介绍和讨论。总计划还要求为每届会议的全体发言分配50分钟的时间，为提问和讨论留出大约10分钟的时间。在全体发言之后，将有三个30分钟的演讲，每个演讲有10分钟的提问时间。会议结束时将由主要发言者/主席主持一次小组讨论。这类小型会议的优势在于，与大型全国性会议形式(如毒理学会(SOT))相比，它们更有利于讨论和交流思想。最后一节预留给商业公司代表的演讲，突出最先进的设备，这些设备将使毒物学家能够进行环境研究。我们计划联系相关期刊的编辑，找到发表这次会议记录的地点，因此，这次会议的赞助者将远远超出会议的参与者，延伸到世界各地的环境研究人员。

DESCRIPTION (provided by applicant) Systems biology has become a major field -coming on the heels of the rise in prominence and acceptance of genomics and proteomics. Toxicoproteomics and toxicogenomics are become increasing important techniques in the arsenal of toxicologists -allowing us to assay the effects of environmental xenobiotics ultimately on the entire genome or proteome instead of isolated genes and their products. The role of systems biology in this paradigm is to develop and deploy the "tools" needed to analyze the vast amounts of data that is generated using these techniques. These tools include new bioinformatic techniques for analyzing these data to determine which genes and/or their products that have been altered by the environmental agents but also modeling software that allow us to conduct experiments in silica. In silica modeling will likely be instrumental in the understanding of the toxicology of mixtures. The purpose of this conference is to provide a mechanism for the effective exchange of ideas and methods between scientists that are conducting toxicoproteomics, toxicogenomics, bioinformatics and biological modeling environmental research. The overall plan for the agenda is to highlight relevant environmental exposure models that are appropriate for new toxicogenomic/toxicoproteomic data collection, presentations and discussion of cutting-edge research using toxicogenomics and toxicoproteomics and then follow this with presentations on state-of-art bioinformatic programs and techniques. Finally, the latest biological modeling tools will be introduced and discussed. The general plan also calls for the allocation of a 50 minute time block for a plenary presentation for each session, reserving approximately 10 minutes of that time for questions and discussion. The plenary presentation will be followed by three 30 minute presentations, each with a 10 minute question time. The session will be concluded with a panel discussion led by the primary speaker/chair. The advantage of smaller meetings, such as this, is that they are more conducive to discussion and exchange of ideas in contrast to larger national meeting formats, e. g., Society of Toxicology (SOT). The final session is reserved for presentations by representatives of commercial companies to highlight state-of-art equipment that will allow toxicologists to perform environmental research. We plan to contact editors of relevant journals to find a venue to publish the proceedings of this conference, thus, the benefactors of this conference will extend far beyond the participants of the conference to environmental researchers worldwide.