2005 CELL BIOLOGY OF METALS GORDON CONFERENCE

2005 金属细胞生物学戈登会议

• 批准号: 6932650
• 负责人: Dennis R. Winge
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932650
• 关键词: cell biology; copper; iron; meeting /conference /symposium; metal metabolism; travel; zinc

DESCRIPTION (provided by applicant): The principal objective of the 2005 Cell Biology of Metals Gordon Conference is to inaugurate a new Gordon Conference on this rapidly expanding sub-discipline. The first meeting will bring together scientists, ranging from established investigators to graduate students, to present and discuss the most recent advances in cell physiology of copper, iron and zinc ions in eukaryotic systems. The questions encompassed by cell biology of metals are how do cells achieve metal ion homeostasis and how do cells specifically sense diverse metal ions in these mechanisms? Ultimately, such systems facilitate the correct metals locating to the approximately one-third of proteins that require metal-cofactors for folding or catalysis. Sessions will deal with metal ion homeostasis in the central nervous system, intertissue regulation of metal ion homeostasis, transport of metal ions and metal ion complexes, intracellular trafficking of metal ions, metal ion signaling and global analyses of metals in cells. An important goal is to address the interconnections that exist in homeostatic mechanisms of different metal ions. The meeting aims to draw together the investigators and trainees carrying out research on the mentioned topics in attempt to promote communication, collaborations and share advances in methodologies. The novelty of the Cell Biology of Metals conference lies in the unique focus on cell biological issues related to metal ions and the integrated consideration of multiple metal ions that are essential to life.

描述（由申请人提供）：2005年金属细胞生物学戈登会议的主要目标是就这一迅速扩展的子学科开创一个新的戈登会议。第一次会议将汇集科学家，从既定的研究人员到研究生，介绍和讨论铜，铁和锌离子在真核系统中的细胞生理学的最新进展。金属的细胞生物学所包含的问题是细胞如何实现金属离子的稳态，以及细胞如何在这些机制中特异性地感知不同的金属离子。最终，这样的系统有助于正确的金属定位到大约三分之一的蛋白质，这些蛋白质需要金属辅因子进行折叠或催化。会议将涉及金属离子稳态在中枢神经系统，金属离子稳态的组织间调节，金属离子和金属离子络合物的运输，金属离子的细胞内运输，金属离子信号传导和金属在细胞中的全球分析。一个重要的目标是解决存在于不同金属离子的稳态机制中的互连。会议的目的是召集就上述专题开展研究的调查人员和受训人员，以促进沟通、合作和分享方法方面的进展。金属细胞生物学会议的新奇之处在于独特地关注与金属离子相关的细胞生物学问题，并综合考虑对生命至关重要的多种金属离子。