2007 Cell Biology of Metals Gordon Research Conference

2007年金属细胞生物学戈登研究会议

• 批准号: 7276348
• 负责人: ANDREW B. DANCIS
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-11 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276348
• 关键词: Address; Biological; Categories; Cells; Cellular Structures; Cellular biology; Chelating Agents; Chloroplasts; Copper; Destinations; Development; Disease; Eukaryotic Cell; Goals; Homeostasis; Ions; Iron; Link; Membrane; Metalloproteins; Metals; Mitochondria; Molecular Chaperones; Organelles; Pathway interactions; Physiological; Proteins; Range; Research; Research Personnel; Scientist; Students; Translations; Zinc; cofactor; intracellular protein transport; programs; protein transport; symposium; trafficking; transcription factor; uptake

DESCRIPTION (provided by applicant): The principal objective of the 2006 Cell Biology of Metals Gordon Conference is to provide a forum for presentation of new developments and for exchanging ideas in this emerging field. The meeting will bring together scientists, ranging from established investigators to graduate students, to present and discuss the most recent advances in eukaryotic cell biology involving copper, iron and zinc ions and the corresponding metalloproteins. The cell biology of metals encompasses the uptake, distribution and use of metals in cells and organelles. Metals are taken up across membranes and are directed to various cellular destinations, ultimately finding their way into the correct metalloproteins. Intricate mechanisms control uptake, distribution, trafficking, and insertion into proteins. Transporters, chelators, metal cofactors, chaperones (classic sense), metallochaperones, transcription factors and translation regulators are involved. The level of complexity equals that of the protein trafficking pathways that have been characterized in modern cell biology. An important goal is to understand how protein trafficking pathways and metal trafficking pathways are integrated and intersect. Other goals are to understand how cells achieve metal ion homeostasis, how cells sense diverse metal ions, and how homeostatic mechanisms for different metal ions are interconnected. Cellular malfunction or disease ensue if any of the steps in metal homeostasis are perturbed, and the meeting will bring out these disease links. The sessions will generally be organized according to cell structure, cutting across metals (Fe, Cu, Zn, Mo) and evolutionary categories. Sessions are planned to address transport of metals into cells, metals in endocytic and secretory compartments, mitochondria and iron, mitochondria and copper, metals in chloroplasts, metal cofactors, metals in global regulatory programs and metal allocation and sensing. The novelty of the Cell Biology of Metals Conference lies in its unique focus on cell biological issues related to metal ions and the focus on multiple physiological ions.

描述（由申请人提供）：2006年金属细胞生物学戈登会议的主要目的是提供一个论坛，介绍这一新兴领域的新发展和交流思想。会议将汇集科学家，从成熟的研究人员到研究生，介绍和讨论真核细胞生物学的最新进展，涉及铜、铁和锌离子以及相应的金属蛋白。金属的细胞生物学包括金属在细胞和细胞器中的吸收、分布和利用。金属被膜吸收，并被引导到不同的细胞目的地，最终找到进入正确金属蛋白的途径。复杂的机制控制着蛋白质的摄取、分布、运输和插入。涉及转运蛋白、螯合剂、金属辅因子、伴侣蛋白（经典意义）、金属伴侣蛋白、转录因子和翻译调节因子。其复杂程度相当于现代细胞生物学中所描述的蛋白质运输途径。一个重要的目标是了解蛋白质运输途径和金属运输途径是如何整合和交叉的。其他目标是了解细胞如何实现金属离子稳态，细胞如何感知不同的金属离子，以及不同金属离子的稳态机制如何相互关联。如果金属稳态中的任何一个步骤被扰乱，细胞功能障碍或疾病就会随之而来，而会议将揭示这些疾病的联系。