CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGING

描述（由申请人提供）：第11届生物EPR光谱、成像和自旋捕获国际会议（EPR-2005）将于2005年9月4日至9日在俄亥俄州的哥伦布举行。 会议将重点讨论广泛的电子顺磁共振（EPR）方法，以研究与人类健康有关的生物过程。 两年一次的EPR会议/研讨会已成为讨论电子和核磁共振（EPR，MRI和PEDRI）技术进展的主要平台。 在过去的几十年中，自由基在许多疾病的发病机制中的作用已得到充分认识，包括癌症、动脉粥样硬化、缺血-再灌注损伤、中风、糖尿病血管疾病和各种炎症性疾病。这些自由基统称为“活性氧/氮物质（ROS/RNS）"，在应激下在生物环境中产生，并通过导致组织损伤的级联反应传播。在这些自由基的检测、表征和定量方面已经取得了很大的进展。 EPR光谱仍然是最受欢迎的技术，能够在体外和体内直接检测和定量这些自由基。当与成像的功率相结合时，获得关于组织中的自由基的分布的空间分辨信息已经成为该技术的独特特征。尽管EPR技术具有许多潜力和优点，但在生物学和医学自由基领域的研究人员中尚未完全认识到EPR技术。 其主要原因是缺乏对该技术及其独特功能的认识。为了在非EPR社区中传播EPR成像技术的优点，我们正在组织为期5天的研讨会/会议，重点介绍体内EPR光谱和成像技术的生物医学应用。与会者将包括EPR科学家，初级教师，年轻的研究人员，博士生和博士后研究员来自世界各地。 本次会议的亮点之一是包括，教育和鼓励妇女和少数民族学生以及EPR领域的新人。 会议汇集了应用研究专家以及仪器，技术，软件和数据库的建设者和开发者。本次会议的专题讨论会旨在继续进行富有成效的思想交流，这是该领域取得成功进展的巨大推动力。2005年环境工作报告将保持传统的海报会议和全体讲座形式，突出每个主要领域的重大进展。 在此征集的资金需要为来自美国的36名年轻科学家（研究生，博士后研究科学家和年轻研究人员）提供部分旅行支持，这些科学家是从那些贡献研究论文的人中挑选出来的，另外20名参与者将被邀请进行口头演讲。 与会者是否有资格获得旅费资助，将根据由国际咨询委员会美国成员组成的委员会为本次会议制定的一套标准来决定。 将特别重视少数民族科学家和女科学家，鼓励他们积极参与。

DESCRIPTION (provided by applicant): The 11th International Conference on the Biological EPR Spectroscopy, Imaging, and Spin-Trapping (EPR-2005) will be held September 4-9, 2005 in Columbus, Ohio. The meeting will focus on a wide spectrum of electron paramagnetic resonance (EPR) methods to study the biological processes pertinent to human health. The biennial EPR Conference/Workshop has become the major platform to discuss advances in electron and nuclear magnetic resonance (EPR, MRI, and PEDRI) techniques. During the last couple of decades the role of free radicals has been well recognized in the pathogenesis of many diseases, including cancer, atherosclerosis, ischemia-reperfusion injury, stroke, diabetic vascular disease, and a variety of inflammatory diseases. The radicals, collectively termed as "reactive oxygen/nitrogen species (ROS/RNS)", are generated in the biological milieu under stress and propagated through a cascade of reactions leading to tissue damage. A great deal of progress has been made in the detection, characterization and quantification of these radicals. The EPR spectroscopy still remains the most sought after technique that enables direct detection and quantification of these radicals in vitro as well as in vivo. Obtaining spatially resolved information on the distribution of the radicals in the tissue, when combined with the power of imaging, has become a unique feature of this technique. In spite of many potentials and advantages, the EPR technique is not yet completely recognized among the investigators in the field of free radicals in biology and medicine. The prime reason for this is the lack of awareness of the technique and its unique capabilities. In order to disseminate the virtues of the EPR imaging technology among the non-EPR community, we are organizing a 5-day workshop/conference, which will highlight the biomedical applications of the in vivo EPR spectroscopy and imaging technology. Participants will include EPR scientists, junior faculty, young investigators, doctoral candidates and post-doctoral fellows from all over the world. One of the highlights of this conference is to include, educate, and encourage women and minority students as well as newcomers to the EPR field. The conference brings together the experts on application studies as well as the builders and developers of instrumentation, techniques, software, and databases. Symposia at this conference are designed for the continued fruitful cross-fertilization of ideas that has been a tremendous driving force behind the successful advances in this field. EPR- 2005 will maintain the traditional format of poster sessions and plenary lectures, which highlight major advances in each of the major areas. The funds solicited here are needed to provide partial travel support to 36 younger scientists from the U.S. (graduate students, post-doctoral research scientists, and young investigators) following selection among those who have contributed research papers, and further 20 of those participants will be invited for oral presentations. The eligibility of a participant to receive travel support will be decided according to a set of criteria set by a committee consisting of the U.S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation.