2006 Biophysical Discussions - Molecuar Motors: Point Counterpoint

2006 生物物理讨论 - 分子马达：点对位

• 批准号: 7174436
• 负责人: STEVEN S ROSENFELD
• 金额: $ 0.5万
• 依托单位: BIOPHYSICAL SOCIETY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2007-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174436
• 关键词: cytoskeletal proteins; enzyme activity; meeting /conference /symposium; protein structure function; protein transport; travel

DESCRIPTION (provided by applicant): The 2006 Biophysical Society Discussions, entitled "Molecular Motors-Point Counterpoint", is devoted to a critical evaluation of the current state of our knowledge about these diverse and pathophysiologically-relevant enzymatic machines-a discussion that will help resolve outstanding questions regarding motor function and lead to the development of new ideas about future directions. It will be held in Asilomar, California, from October 19-22, 2006. Although this field has made rapid progress in recent years, major unresolved questions remain. Do all motors have common structural elements that are shared by distinct motor superfamilies? If so, what does this tell us about what it takes to construct a motor? How do different motors convert the energy of ATP hydrolysis into force and movement, and are similar mechanisms used by all of these? How do motors determine their direction of movement, and how are they regulated? What can structural and enzymatic studies in vitro tell us about how a motor functions in the cell, and vice versa. A diverse group of speakers and participants with a broad range of expertise from molecular structure to single molecule mechanics to molecular genetics and cell biology will interact in a forum designed to critically evaluate our state of knowledge and develop new ideas regarding the future direction of research efforts in this field. Addressing these unresolved issues has become a particularly pressing concern as we have come to appreciate the central role that molecular motors play in the pathophysiology of a wide range of diseases-from cancer to atherosclerosis to amyotrophic lateral sclerosis to Alzheimer's disease.

描述（由申请人提供）：2006年生物物理学会讨论，题为“分子马达-点对位”，致力于对我们对这些不同的和病理生理学相关的酶机制的知识的当前状态进行批判性评估-讨论将有助于解决关于运动功能的突出问题，并导致关于未来方向的新想法的发展。它将于2006年10月19日至22日在加州的阿西洛马举行。尽管近年来这一领域取得了迅速进展，但仍存在一些重大的未决问题。所有的马达都有不同马达超家族共有的共同结构元件吗？如果是这样的话，这告诉我们什么是需要建造一个马达？不同的马达如何将ATP水解的能量转化为力和运动，所有这些马达使用的机制是否相似？马达是如何决定它们的运动方向的，它们又是如何被调节的？体外结构和酶研究能告诉我们什么关于马达在细胞中的功能，反之亦然。一个多样化的演讲者和参与者群体，从分子结构到单分子力学到分子遗传学和细胞生物学，他们将在一个论坛上进行互动，该论坛旨在批判性地评估我们的知识状况，并就该领域未来的研究方向提出新的想法。解决这些悬而未决的问题已经成为一个特别紧迫的问题，因为我们已经认识到，分子马达在一系列疾病的病理生理学中发挥的核心作用，从癌症到动脉粥样硬化，肌萎缩侧索硬化，阿尔茨海默氏病。