2006 Biophysical Discussions - Molecuar Motors: Point Counterpoint

描述(申请人提供)：2006年生物物理学会讨论，题为“分子马达-点对应点”，致力于对我们对这些多样化和病理生理学相关的酶机器的知识现状进行批判性评估-这一讨论将有助于解决有关运动功能的悬而未决的问题，并导致对未来方向的新想法的发展。它将于2006年10月19日至22日在加利福尼亚州的阿西洛马举行。尽管这一领域近年来取得了快速进展，但仍存在一些重大悬而未决的问题。是否所有马达都有不同马达超级家族所共有的共同结构元素？如果是这样的话，这能告诉我们建造一台发动机需要什么呢？不同的马达如何将ATP水解的能量转化为力和运动，所有这些马达都使用类似的机制吗？马达是如何决定它们的运动方向的，它们又是如何被调节的？体外的结构和酶研究能告诉我们什么，关于运动如何在细胞中发挥作用，反之亦然。从分子结构到单分子力学再到分子遗传学和细胞生物学，拥有广泛专业知识的不同演讲者和参与者将在一个旨在批判性地评估我们的知识状况并就该领域未来研究方向提出新想法的论坛上进行互动。随着我们逐渐认识到分子马达在从癌症到动脉粥样硬化、肌萎缩侧索硬化症到阿尔茨海默病等一系列疾病的病理生理学中发挥的核心作用，解决这些悬而未决的问题已经成为一个特别紧迫的问题。

DESCRIPTION (provided by applicant): The 2006 Biophysical Society Discussions, entitled "Molecular Motors-Point Counterpoint", is devoted to a critical evaluation of the current state of our knowledge about these diverse and pathophysiologically-relevant enzymatic machines-a discussion that will help resolve outstanding questions regarding motor function and lead to the development of new ideas about future directions. It will be held in Asilomar, California, from October 19-22, 2006. Although this field has made rapid progress in recent years, major unresolved questions remain. Do all motors have common structural elements that are shared by distinct motor superfamilies? If so, what does this tell us about what it takes to construct a motor? How do different motors convert the energy of ATP hydrolysis into force and movement, and are similar mechanisms used by all of these? How do motors determine their direction of movement, and how are they regulated? What can structural and enzymatic studies in vitro tell us about how a motor functions in the cell, and vice versa. A diverse group of speakers and participants with a broad range of expertise from molecular structure to single molecule mechanics to molecular genetics and cell biology will interact in a forum designed to critically evaluate our state of knowledge and develop new ideas regarding the future direction of research efforts in this field. Addressing these unresolved issues has become a particularly pressing concern as we have come to appreciate the central role that molecular motors play in the pathophysiology of a wide range of diseases-from cancer to atherosclerosis to amyotrophic lateral sclerosis to Alzheimer's disease.