Biofilm-Material Interactions-New Tools, Technologies, and Opportunities

描述（由申请人提供）：植入生物医学器械和组织表面的细菌感染对人类健康构成了日益严重的威胁，并产生了显著的临床和经济后果。在许多感染中，细菌附着在医疗器械或受损组织的表面，随后发展成高度合作的社区，称为生物膜。生物膜中的细菌受到宿主防御和抗生素的良好保护，几乎所有这些都是为了对抗处于休眠状态的细菌而开发的。由于缺乏替代策略，从导管到整形外科植入物的受感染生物医学设备被简单地移除。特别是对于留置装置，这样的手术可能实质上损害后续翻修手术的成功，产生广泛的患者不适，并导致医疗保健成本迅速上升。解决这一复杂问题的技术部分在于：（1）利用纳米技术的最近和未来进展来开发多功能表面，其抵抗生物膜形成并减少感染的发生率，同时促进健康组织的粘附，（2）提高高-通过体外工具来模拟生物膜生理学并量化生物膜对候选治疗策略的反应，以促进将有前途的实验室概念快速安全地转化为临床实践。本次研讨会的一个关键目标是提供一个论坛，从广泛不同的跨学科的角度来评估，如何纳米技术，微反应器系统，表面化学和微生物学的现代概念可以整合和利用，以彻底改变我们的方式都研究和应对生物膜相关的传染病在未来十年。

DESCRIPTION (provided by applicant): Bacterial infections of implanted biomedical devices and tissue surfaces constitute an ever-increasing threat to human health with significant clinical and economic consequences. In many infections, bacteria attach to the surfaces of medical devices or compromised tissue and subsequently develop into highly cooperative communities known as biofilms. Bacteria in a biofilm are well protected from host defenses and antibiotics, almost all of which have been developed to combat bacteria in their planktonic state. Lacking alternative strategies, infected biomedical devices ranging from catheters to orthopedic implants are simply removed. Particularly for in-dwelling devices, such a procedure can substantially compromise the success of a subsequent revision surgery, produce extensive patient discomfort, and lead to rapidly escalating health-care costs. A technology part of a solution to this complex problem resides in: (1) the exploitation of recent and future advances in nanotechnology to develop multifunctional surfaces which resist biofilm formation and reduce the incidence of infection while promoting the adhesion of healthy tissue, and (2) increasing the predictive capability of high-throughput in vitro tools to emulate biofilm physiology and quantify biofilm responses to candidate treatment strategies in order to facilitate rapid and safe translation of promising laboratory concepts into clinical practice. A key goal of this symposium is to provide a forum to assess, from widely varying interdisciplinary perspectives, how nanotechnology, microreactor systems, surface chemistry, and modern concepts of microbiology can be integrated and exploited to revolutionize the way we both study and respond to biofilm-associated infectious diseases over the coming decade.