DNA Replication and Genome Integrity

DNA 复制和基因组完整性

• 批准号: 7162244
• 负责人: Matthew D. Weitzman
• 金额: $ 0.5万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162244
• 关键词: DNA replication; genome; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This proposal requests funds to sustain a biennial meeting entitled "DNA Replication and Genome Integrity" that will be held August 9-13, 2006, at the Salk Institute in La Jolla, California. This meeting is designed to emphasize the intersection of DNA replication with DNA repair and genome stability. These areas are relevant to human health, including the etiology, diagnosis and treatment of cancer, aging, and developmental diseases. The meeting will encourage a deeper understanding of links between cellular replication and repair systems. Outstanding researchers have been invited to serve as chairs and speakers in sessions that will cover topics that include replication origins, initiation of DNA replication, replication fork progression, chromatin, checkpoints, chromosome dynamics, DNA repair, recombination, and cancer therapeutics. These chairs will provide in-depth introductions to the most important concepts and unresolved problems in each field. All other presentations will be chosen from submitted abstracts for either oral talks or posters. In this way we will ensure that the forefront of research is presented and will encourage active participation of younger researchers. The Organizing Committee consists of four investigators from two institutions: Judith Campbell (CalTech), Vicki Lundblad (Salk), Geoff Wahl (Salk), and Matthew Weitzman (Salk). The Organizing Committee will be responsible for inviting the session chairs, for selection of the other speakers and participants from submitted abstracts and for choosing recipients for travel awards. The meeting will be held in the Salk Conference Center, a well-organized facility with much experience in conducting international meetings. A concerted effort will be made at every stage of the planning and organization of the meeting to ensure inclusion of women and minorities. We request funds to cover the travel costs and accommodation for a Keynote speaker, invited speakers, and travel scholarships (some of which will be allocated specifically for minorities). This conference complements both temporally and geographically the current biennial DNA replication meeting held at Cold Spring Harbor in odd-numbered years. This will be the fourth time that we have organized this meeting and its past success has shown that it fills a thematic, geographical and timely niche. The meeting has provided a forum for discussion of the most topical issues confronting eukaryotic DNA replication and has fostered interactions between junior and senior investigators. Due to its West Coast location, increased participation from West Coast and Pacific labs is expected. We anticipate that the topics presented and the comfortable venue will encourage new researchers to enter this important field, as well as provide experienced researchers with the new approaches needed to make significant future advances.

描述（由申请人提供）：该提案要求资金维持题为“ DNA复制和基因组完整性”的两年一度的会议，该会议将于2006年8月9日至13日在加利福尼亚州拉霍拉的Salk Institute举行。 这次会议旨在强调DNA复制与DNA修复和基因组稳定性的相交。 这些领域与人类健康有关，包括癌症，衰老和发育疾病的病因，诊断和治疗。 会议将鼓励对细胞复制和维修系统之间的联系有更深入的了解。杰出的研究人员应邀请在会议上担任主席和演讲者，这些主题将涵盖包括复制起源，DNA复制的启动，复制叉进展，染色体，检查点，染色体动力学，DNA修复，重组，重组和癌症治疗的主题。这些椅子将深入介绍每个领域中最重要的概念和未解决的问题。 所有其他演讲将从提交的口头谈判或海报的摘要中选择。 通过这种方式，我们将确保提出研究的最前沿，并鼓励年轻的研究人员积极参与。 组织委员会由来自两个机构的四名调查人员组成：朱迪思·坎贝尔（Caltech），维基·伦德布拉德（Vicki Lundblad）（Salk），Geoff Wahl（Salk）和Matthew Weitzman（Salk）。 组织委员会将负责邀请会议主席，从提交摘要中选择其他发言人和参与者，并选择获得旅行奖的接收者。 该会议将在Salk会议中心举行，该中心组织良好的设施，在举行国际会议方面有很多经验。 会议的计划和组织的每个阶段都会进行一致的努力，以确保妇女和少数群体的纳入。 我们要求资金支付主题演讲者的旅行费用和住宿，并邀请演讲者和旅行奖学金（其中一些将专门为少数民族分配）。这次会议在时间和地理上都在当前的双年展DNA复制会议上补充了奇数年的冷春港。 这将是我们第四次组织这次会议，其过去的成功表明，它充满了主题，地理和及时的利基市场。 该会议为讨论真核DNA复制面临的最新问题提供了论坛，并促进了初级和高级研究人员之间的互动。 由于其西海岸的位置，预计西海岸和太平洋实验室的参与会增加。 我们预计提出的主题和舒适的场地将鼓励新的研究人员进入这一重要领域，并为经验丰富的研究人员提供取得重大进展所需的新方法。