2006 Tetrapyrroles Chemistry and Biology of Gordon Research Conference

描述(由申请人提供)： 这项拨款申请请求支持在罗德岛州纽波特的萨尔维里贾纳大学举行的第21届戈登四角化学和生物学研究会议(GRC)(2006年7月23-28日)。自1966年以来，这个两年一度的跨学科会议促进了基础科学家之间的合作，包括生物化学家、生物学家、化学家和对四种角色感兴趣的临床医生。在各种蛋白质环境中，四氢吡咯具有不同的作用，提供氧化还原催化剂以获取光能，并激活、传递和感知双原子气体(如氧、一氧化碳和一氧化氮)，通常作为信号系统。四吡咯是必需的营养素(如维生素B12)；通过转录和翻译效应(如血红素)调节蛋白质的表达；并为光动力癌症治疗和放射性核素的靶向递送提供新的治疗剂。但由于它们的光动力学、毒性和亲脂性，一些四吡咯(例如，卟啉、胆红素)会在皮肤、肝脏和大脑的细胞中积累，产生不同的病理现象(例如，卟啉症)。因此，GRC是基础研究人员和应用研究人员就四元角色进行交流的重要场所，也是完善生物医药行业正在开发的新工具和疗法的重要场所。为展示这些研究人员所取得的进展，专门设计了一些会议，包括新的会议：四吡咯贩运(例如细胞内转运蛋白)；四吡咯在复杂生物过程中的作用(例如昼夜节律；全球铁的动态平衡)；纳米结构和人造血红素蛋白；以及关于卟啉症的讲习班，重点是代谢组学。该计划包括28名特邀演讲者、一名全体讲师和9名讨论领袖，他们是根据他们在科学上的卓越表现和最近为该计划的气息做出重大贡献的创新工作而被选中的。剩下的大约100名与会者将被挑选出来，以确保在学术界、医学研究机构和工业界中有广泛的妇女、族裔和来自不同学科的青年科学家的代表性。这个已建立的GRC的优势在于它的学科多样性，专注于新的未发表的作品，讨论的时间，非正式的气氛和禁止传播会议记录。

DESCRIPTION (provided by applicant): This grant application requests support for the 21st Gordon Research Conference (GRC) on the Chemistry and Biology of Tetrapyrroles at Salve Regina University, Newport, Rl (July 23-28, 2006). Since1966, this biennial interdisciplinary conference has fostered collaborations between basic scientists including biochemists, biologists, chemists and clinicians interested in tetrapyrroles. In a variety of protein environments, tetrapyrroles have diverse roles providing redox catalysts to harvest light energy and to activate, deliver and sense diatomic gases (e.g. oxygen, carbon monoxide and nitric oxide) often acting as signaling systems. Tetrapyrroles are essential nutrients (e.g. vitamin B12); regulate protein expression via transcriptional and translational effects (e.g. heme); and provide novel therapeutic agents for photodynamic cancer therapy and targeted delivery of radionuclides. But due to their photodynamic, toxic and lipophilic properties some tetrapyrroles (e.g. porphyrins, bilirubin) accumulate in cells of the skin, liver and brain, producing diverse pathologies (e.g. porphyrias). Thus, this GRC represents an important venue for exchange between basic and applied researchers on tetrapyrroles and for refinement of new tools and therapies under development by the biomedical industry. Sessions have been specifically devised to showcase the advances made by these investigators including new sessions: tetrapyrrole trafficking (e.g. intracellular transporters); tetrapyrroles in complex biological processes (e.g. circadian rhythms; global iron homeostasis); nanostructures and artificial heme-proteins; and, a workshop on the porphyrias with a focus on metabolomics. This program includes 28 invited speakers, a plenary lecturer, and 9 discussion leaders, selected for their scientific excellence and recent innovative work that makes significant contributions to the breath of the program. The remaining approximately 100 conferees will be chosen to ensure a broad representation of women, ethnicity and young scientists from various disciplines in academia, medical research institutions and industry. The strengths of this established GRC are its disciplinary diversity, focus on new unpublished work, time for discussion, informal atmosphere and ban on dissemination of conference proceedings.