2006 Tetrapyrroles Chemistry and Biology of Gordon Research Conference

描述（由申请人提供）： 此资助申请请求对在Salve Regina University，纽波特，RI（2006年7月23-28日）举行的关于四吡咯的化学和生物学的第21届戈登研究会议（GRC）的支持。自1966年以来，这个两年一度的跨学科会议促进了基础科学家之间的合作，包括生物化学家，生物学家，化学家和对四吡咯感兴趣的临床医生。在各种蛋白质环境中，四吡咯具有不同的作用，提供氧化还原催化剂以收获光能并活化、递送和感测通常充当信号传导系统的双原子气体（例如氧气、一氧化碳和一氧化氮）。四吡咯是必需营养素（例如维生素B12）;通过转录和翻译效应（例如血红素）调节蛋白质表达;并提供用于光动力癌症治疗和放射性核素靶向递送的新型治疗剂。但是由于它们的光动力学、毒性和亲脂性，一些四吡咯（例如卟啉、胆红素）在皮肤、肝脏和大脑的细胞中积累，产生不同的病理（例如卟啉症）。因此，该GRC代表了四吡咯基础和应用研究人员之间的交流以及生物医学行业正在开发的新工具和疗法的改进的重要场所。会议专门设计，以展示这些研究人员取得的进展，包括新的会议：四吡咯贩运（例如细胞内转运蛋白）;复杂生物过程中的四吡咯（例如昼夜节律;全球铁稳态）;纳米结构和人工血红素蛋白;以及，关于卟啉的研讨会，重点是代谢组学。该计划包括28名特邀演讲者，一名全体讲师和9名讨论负责人，他们因其科学卓越和最近的创新工作而被选中，为该计划的呼吸做出了重大贡献。将挑选其余约100名与会者，以确保来自学术界、医学研究机构和工业界各学科的妇女、族裔和青年科学家的广泛代表性。该研究中心的优势在于其学科多样性，专注于新的未发表的工作，讨论时间，非正式的气氛和禁止传播会议记录。

DESCRIPTION (provided by applicant): This grant application requests support for the 21st Gordon Research Conference (GRC) on the Chemistry and Biology of Tetrapyrroles at Salve Regina University, Newport, Rl (July 23-28, 2006). Since1966, this biennial interdisciplinary conference has fostered collaborations between basic scientists including biochemists, biologists, chemists and clinicians interested in tetrapyrroles. In a variety of protein environments, tetrapyrroles have diverse roles providing redox catalysts to harvest light energy and to activate, deliver and sense diatomic gases (e.g. oxygen, carbon monoxide and nitric oxide) often acting as signaling systems. Tetrapyrroles are essential nutrients (e.g. vitamin B12); regulate protein expression via transcriptional and translational effects (e.g. heme); and provide novel therapeutic agents for photodynamic cancer therapy and targeted delivery of radionuclides. But due to their photodynamic, toxic and lipophilic properties some tetrapyrroles (e.g. porphyrins, bilirubin) accumulate in cells of the skin, liver and brain, producing diverse pathologies (e.g. porphyrias). Thus, this GRC represents an important venue for exchange between basic and applied researchers on tetrapyrroles and for refinement of new tools and therapies under development by the biomedical industry. Sessions have been specifically devised to showcase the advances made by these investigators including new sessions: tetrapyrrole trafficking (e.g. intracellular transporters); tetrapyrroles in complex biological processes (e.g. circadian rhythms; global iron homeostasis); nanostructures and artificial heme-proteins; and, a workshop on the porphyrias with a focus on metabolomics. This program includes 28 invited speakers, a plenary lecturer, and 9 discussion leaders, selected for their scientific excellence and recent innovative work that makes significant contributions to the breath of the program. The remaining approximately 100 conferees will be chosen to ensure a broad representation of women, ethnicity and young scientists from various disciplines in academia, medical research institutions and industry. The strengths of this established GRC are its disciplinary diversity, focus on new unpublished work, time for discussion, informal atmosphere and ban on dissemination of conference proceedings.