Membrane Organisation by Tetraspanins and Small Multi-transmembrane

我们要求为FASEB会议提供部分资金，该会议的主题是 Tetraspanins和小多跨膜蛋白“将在Omni Tucson举行 国家高尔夫度假村和温泉，图森，亚利桑那州，2006年7月22日至27日。这次会议的一个主要主题 Tetraspanin会议是关于这些蛋白质在免疫系统中的作用。四氢杨梅素， 包括CD9、CD37、CD53、CD63、CD81、CD82、CD151和TSSC6 免疫系统的所有主要细胞和过程。因此，他们在 调节体液免疫、B细胞迁移、浆细胞建立、T细胞受体 信号和共刺激信号、抗原提呈、黏附和迁移 中性粒细胞和白细胞跨内皮细胞迁移。这些Tetraspanin功能具有 对免疫问题的影响包括自身免疫性疾病，血细胞肿瘤， 过敏原诱导的过敏、炎症和自身免疫表现 与丙型肝炎相关的许多Tetraspanins可以调节信号和膜 它们的伴侣蛋白，包括整合素，T细胞受体， 和生长因子受体。此外，Tetraspanins在发育和发育过程中发挥作用 神经细胞的功能，它们可以作为病毒和细菌的受体 病原体。因此，Tetraspanins不仅在免疫系统中发挥作用，而且在 癌症、神经系统疾病和传染病。对Tetraspanin的机理认识 功能只是在最近才变得明显。一个令人兴奋的新理解是 Tetrspanins形成独特的膜微域，类似于神经鞘糖脂 浓缩的“木筏”，用来分隔膜成分和蛋白质。此外, 越来越多的证据表明，这些微域可能介导膜融合。 事件。这次真正独一无二的FASEB会议将汇聚来自世界各地 介绍和讨论Tetrspanin最新进展的专业多样性 研究。出席会议的调查员通常不会在会议上相遇。 在他们的学科范围内，没有其他地方可以在这个高度跨学科的地方 主题已被解决。这次会议将为交流提供一个独特的机会。 跨越学科界限的想法、试剂和发现，预计将促进 协作，这构成了理解Tetraspanin的重大进展的基础 生物学。

We request partial funding for a FASEB conference on "Membrane Organization by Tetraspanins and Small Multi-transmembrane Proteins" to be held at Omni Tucson National Golf Resort and Spa, Tucson, Arizona, July 22-27 2006. A major theme in this tetraspanin conference is the roles of these proteins in the immune system. Tetraspanins, including CD9, CD37, CD53, CD63, CD81, CD82, CD151 and TSSC6, are involved in all the major cells and processes of the immune system. Thus, they have a role in regulating humoral immunity, B cell migration, plasma cell establishment, T cell receptor signaling and costimulatory signals, antigen presentation, adhesion and migration of neutrophils, and leukocyte transendothelial migration. These tetraspanin functions have implications for immunity problems including autoimmune diseases, blood cell neoplasm, allergen-induced hypersensitivity, inflammation, and autoimmune manifestations associated with hepatitis C. Many tetraspanins can regulate the signaling and membrane compartmentalization of their partner proteins, which include integrins, T cell receptor, and growth factor receptors. In addition, tetraspanins play a role in the development and function of neural cells, and they can serve as the receptors for viral and bacterial pathogen. Therefore, tetraspanins play a role not only in the immune system, but also in cancer, neurological and infectious diseases. Mechanistic understanding of tetraspanin function is only recently becoming evident. One exciting new understanding is that tetraspanins form unique membrane microdomains analogous to the glycosphingolipid enriched "rafts" which serve to partition membrane components and proteins. In addition, growing evidence suggests that these microdomains may mediate membrane fusion events. This truly unique FASEB conference will bring together researchers from a rich diversity of specializations to present and discuss the latest advances in tetraspanin research. The attending investigators generally do not encounter one another at meetings within their disciplines and there is no other venue at which this highly interdisciplinary subject is addressed. This conference will provide a unique opportunity for the exchange of ideas, reagents and discoveries across disciplinary boundaries and is expected to foster collaborations, which form the basis of significant advances in understanding tetraspanin biology.