Membrane Organisation by Tetraspanins and Small Multi-transmembrane

四跨膜蛋白和小型多跨膜的膜组织

• 批准号: 7162144
• 负责人: Tung-Tien Sun
• 金额: $ 1.1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162144
• 关键词: meeting /conference /symposium; protein structure function; tetraspanin; travel

We request partial funding for a FASEB conference on "Membrane Organization by Tetraspanins and Small Multi-transmembrane Proteins" to be held at Omni Tucson National Golf Resort and Spa, Tucson, Arizona, July 22-27 2006. A major theme in this tetraspanin conference is the roles of these proteins in the immune system. Tetraspanins, including CD9, CD37, CD53, CD63, CD81, CD82, CD151 and TSSC6, are involved in all the major cells and processes of the immune system. Thus, they have a role in regulating humoral immunity, B cell migration, plasma cell establishment, T cell receptor signaling and costimulatory signals, antigen presentation, adhesion and migration of neutrophils, and leukocyte transendothelial migration. These tetraspanin functions have implications for immunity problems including autoimmune diseases, blood cell neoplasm, allergen-induced hypersensitivity, inflammation, and autoimmune manifestations associated with hepatitis C. Many tetraspanins can regulate the signaling and membrane compartmentalization of their partner proteins, which include integrins, T cell receptor, and growth factor receptors. In addition, tetraspanins play a role in the development and function of neural cells, and they can serve as the receptors for viral and bacterial pathogen. Therefore, tetraspanins play a role not only in the immune system, but also in cancer, neurological and infectious diseases. Mechanistic understanding of tetraspanin function is only recently becoming evident. One exciting new understanding is that tetraspanins form unique membrane microdomains analogous to the glycosphingolipid enriched "rafts" which serve to partition membrane components and proteins. In addition, growing evidence suggests that these microdomains may mediate membrane fusion events. This truly unique FASEB conference will bring together researchers from a rich diversity of specializations to present and discuss the latest advances in tetraspanin research. The attending investigators generally do not encounter one another at meetings within their disciplines and there is no other venue at which this highly interdisciplinary subject is addressed. This conference will provide a unique opportunity for the exchange of ideas, reagents and discoveries across disciplinary boundaries and is expected to foster collaborations, which form the basis of significant advances in understanding tetraspanin biology.

我们要求为FASEB会议提供部分资金， 四跨膜蛋白和小的多跨膜蛋白”将在全图森举行 国家高尔夫度假村和水疗中心，图森，亚利桑那州，2006年7月22日至27日。其中一个重要的主题是 tetraspanin会议是这些蛋白质在免疫系统中的作用。四跨膜蛋白， 包括CD9、CD37、CD53、CD63、CD81、CD82、CD151和TSSC 6，参与了 免疫系统的所有主要细胞和过程。因此，他们在以下方面发挥作用： 调节体液免疫，B细胞迁移，浆细胞建立，T细胞受体 信号传导和共刺激信号、抗原递呈、粘附和迁移 中性粒细胞和白细胞跨内皮迁移。这些四跨膜蛋白功能具有 对免疫问题的影响，包括自身免疫性疾病，血细胞肿瘤， 过敏原诱导的超敏反应、炎症和自身免疫表现 与丙型肝炎有关。许多四跨膜蛋白可以调节信号转导和膜 它们的伴侣蛋白质，包括整联蛋白，T细胞受体， 和生长因子受体。此外，四跨膜蛋白在发育中发挥作用， 神经细胞的功能，它们可以作为病毒和细菌的受体 病原体因此，四跨膜蛋白不仅在免疫系统中发挥作用，而且在 癌症、神经系统疾病和传染病。对四跨膜蛋白的机制理解 功能只是最近才变得明显。一个令人兴奋的新认识是， 四跨膜蛋白形成类似于鞘糖脂的独特膜微区 富集的“筏”，其用于分隔膜组分和蛋白质。此外，本发明还提供了一种方法， 越来越多的证据表明，这些微区可能介导膜融合 事件这个真正独特的FASEB会议将汇集来自丰富的研究人员， 专业的多样性，介绍和讨论四跨膜蛋白的最新进展 research.出席会议的调查人员一般不会在会议上遇到对方 在他们的学科范围内，没有其他地方可以让这种高度跨学科的 主题已解决。这次会议将为交流提供一个独特的机会， 的想法，试剂和发现跨越学科界限，预计将促进 合作，这构成了理解四跨膜蛋白的重大进展的基础 生物学