2006 CARDIAC REGULATORY MECHANISMS GORDON CONFERENCE

描述(由申请人提供)： 本申请寻求为将于2006年7月16-21日在科尔比-索耶学院(科尔比-索耶，NH)举行的心脏调节机制戈登研究会议(GRC)提供部分资金。这个GRC有着悠久的历史，为来自不同学科的有才华和多产的科学家提供了一种讨论尖端科学的形式，他们都对正常和患病心脏的调节这一主题有共同的兴趣。这次会议的一个主要目标是营造一种包容、热烈、活跃和互动的氛围，创造富有成效的讨论和交流新想法，鼓励每个人都参与其中。多年来，GRC的特殊非正式性质一直是产生新思想和建立新的个人和科学联系的焦点。GRC也是年轻和成熟的调查人员进行有意义的互动的地方。这是心血管科学中一个令人兴奋的时期，因为新技术的出现使我们能够探索正常心脏功能的细胞和分子基础。我们正开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。这一GRC很好地融合了与正常心脏电气和机械特性的调节、心肌细胞信号以及这些过程中导致心脏功能障碍的异常相关的基础科学。2006年拟议的全球资源中心将围绕这些主题展开讨论，讨论若干重要议题。会议将包括 会议致力于钙在细胞信号和心肌收缩调节中的作用，钙调节蛋白的结构和功能及其在心脏病中的作用的最新突破，以及兴奋-收缩偶联和节律产生。将用一天的时间讨论钙作为心脏生长、损伤、心肌细胞死亡和肥大的调节因子的影响。一个相关的会议将讨论用干细胞修复衰竭心脏和诱导正常基因表达模式的最新尝试。安德鲁·麦科洛赫博士将在会议结束时就创造性数学建模和心脏调节途径之间的接口发表主旨演讲。所有会议将包括最新的科学(来自海报投稿)，一如既往，将有充足的时间进行海报会议和非正式的思想交流。

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on July 16-21, 2006. This GRC has a long history of providing a format for discussion of cutting edge science by talented and productive scientists from different disciplines, all with a common interest in the topic of regulation of the normal and diseased heart. A key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that creates productive discussions and exchanges of novel ideas, where everyone is encouraged to participate. The special informal nature of the GRC has through the years been a focal point for the generation of new ideas and for new personal and scientific connections. The GRC is also a place for young and established investigators to have meaningful interactions. This is an exciting time in cardiovascular science because of the advent of novel technologies that allow us to explore the cellular and molecular bases of normal cardiac function. We are beginning to translate these new findings to a better understanding of disease mechanisms, diagnosis, prevention and treatment. This GRC has had a good mix of fundamentalscience related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The GRC proposed for 2006 will expand upon these themes to discuss a number of important topics. The conference will include sessions dedicated to the role of Ca in cell signaling and in the regulation of cardiac contractility, the latest breakthroughs in the structure and function of Ca regulatory proteins and their roles in cardiac diseases, and on excitation-contraction coupling and rhythm generation. One day will be spent discussing the influence of Ca as a modulator of cardiac growth, injury, myocyte death and hypertrophy. A related session will discuss the latest attempts at repairing failing hearts with stem cells and inducing normal patterns of gene expression. The keynote address at the end of the conference will be given by Dr. Andrew McColloch on the interface between creative mathematical modelling and cardiac regulatory pathways. All sessions will include late breaking science (from poster contributions) and as always, there will be ample time for poster sessions and informal interchange of ideas.