Functional regulatory variation in stimulus-responsive myeloid lineage enhancers

我们提出了一种综合的功能基因组学方法来描述支持巨噬细胞/小胶质细胞对免疫和环境刺激的细胞反应的基因调控图景，ii)描述控制巨噬细胞和小胶质细胞对刺激反应的效应基因的启动和/或表达的关键顺式调控元件，以及iii)识别控制巨噬细胞和小胶质细胞对免疫和环境刺激的能力的增强子中自然发生的遗传变异。

we propose an integrated functional genomics approach to i) profile the gene regulatory landscape that underpins the cellular response of macrophages/microglia to immune and environmental stimuli, ii) delineate key cis-regulatory elements that control the priming and/or expression of effector genes in response to stimuli in macrophages and microglial cells, and iii) identify naturally occurring genetic variants in enhancers that control the ability of macrophages and microglia to respond to immune and environmental stimuli.