Functional regulatory variation in stimulus-responsive myeloid lineage enhancers

刺激响应性骨髓谱系增强子的功能调节变化

• 批准号: 2622989
• 金额: --
• 依托单位: Babraham Institute
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2622989
• 关键词: Functional; regulatory; variation; stimulus; responsive

we propose an integrated functional genomics approach to i) profile the gene regulatory landscape that underpins the cellular response of macrophages/microglia to immune and environmental stimuli, ii) delineate key cis-regulatory elements that control the priming and/or expression of effector genes in response to stimuli in macrophages and microglial cells, and iii) identify naturally occurring genetic variants in enhancers that control the ability of macrophages and microglia to respond to immune and environmental stimuli.

我们提出了一种综合的功能基因组学方法：i) 分析支持巨噬细胞/小胶质细胞对免疫和环境刺激的细胞反应的基因调控景观，ii) 描绘控制效应基因响应巨噬细胞和小胶质细胞刺激的启动和/或表达的关键顺式调控元件，以及 iii) 识别增强子中自然发生的遗传变异 控制巨噬细胞和小胶质细胞对免疫和环境刺激做出反应的能力。