Novel Biodegradable Materials for Tissue Engineering

用于组织工程的新型可生物降解材料

• 批准号: 7246695
• 负责人: CATO T. LAURENCIN
• 金额: $ 5.91万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7246695
• 关键词: biodegradable product; biomaterial development /preparation; copolymer; glycolates; laboratory rabbit; laboratory rat; lactates; phosphorus compounds; polymers; tissue /cell culture; tissue engineering

DESCRIPTION (provided by applicant): In recent years emphasis in biomaterial engineering has shifted from biostable materials to biodegradable materials that can degrade to non-toxic products under physiological conditions. Polymers of lactic and glycolic acid and their copolymers poly(lactide-co-glycolide), (PLAGA) are some of the most commonly used biodegradable polymers for medical applications. All these polymers are associated with some limitations, which demand the search for novel biodegradable materials that are biocompatible and bioresponsive. Biodegradable polyphosphazenes, a unique class of inorganic polymer developed recently have the potential to become ideal candidates for various biomedical applications due to their unprecedented synthetic flexibility and versatile properties. PI had previously shown that blending polyphosphazenes with PLAGA can significantly preclude the accumulation of acidic degradation products of PLAGA and associated inflammatory reponses, at the same time can significantly improve their mechanical properties and osteoconductivity. We believe that the synthetic flexibility of polyphosphazenes will allow the design of novel macromolecules, which can for miscible blends with PLAGA and increase the bioactivity. These novel blends due to their well-tuned biodegradability, mechanical and biological properties combined with osteointegrity can serve a variety of needs in orthopaedics. This goal will be achieved via the following specific aims: Specific Aim 1: To design, synthesize and characterize novel biodegradable polyphosphazenes, which can form miscible blends with PLAGA as candidate materials for bone tissue engineering. Specific Aim 2: To construct novel blends of polyphosphazenes with PLAGA and perform optimization studues with these blends focusing on improvements in physico-chemical properties, mechanical properties, in vitro degradation, in vitro mineralization and osteoconductivity. Specific Aim 3: To perform biological evaluation of novel blends of polyphosphazenes with PLAGA using in vivo animal models.

描述（由申请人提供）：近年来，生物材料工程的重点已从生物稳定材料转向可生物降解材料，可生物降解材料在生理条件下可降解为无毒产品。乳酸和乙醇酸的聚合物及其共聚物聚（丙交酯-共-乙交酯）（PLAGA）是用于医疗应用的一些最常用的可生物降解聚合物。所有这些聚合物都有一定的局限性，这就要求寻找具有生物相容性和生物响应性的新型生物可降解材料。可生物降解的聚磷腈是近年来发展起来的一类独特的无机高分子材料，由于其具有前所未有的合成灵活性和多功能性，有可能成为各种生物医学应用的理想候选材料。PI先前已经表明，将聚磷腈与PLAGA共混可以显著地阻止PLAGA的酸性降解产物的积累和相关的炎症反应，同时可以显著地改善其机械性能和骨传导性。我们相信，聚磷腈的合成灵活性将允许设计新的大分子，这可以与PLAGA形成可混溶的共混物，并增加生物活性。这些新型共混物由于其良好的生物降解性、机械和生物学特性以及骨完整性，可以满足骨科的各种需求。这一目标将通过以下具体目标来实现：具体目标1：设计、合成和表征新型可生物降解的聚磷腈，其可以与PLAGA形成可混溶的共混物，作为骨组织工程的候选材料。具体目标二：构建聚磷腈与PLAGA的新型共混物，并对这些共混物进行优化研究，重点关注物理化学性能、机械性能、体外降解、体外矿化和骨传导性的改善。具体目标3：使用体内动物模型对聚磷腈与PLAGA的新型共混物进行生物学评价。