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Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training Program

肌肉骨骼组织再生工程-融合博士培训项目

基本信息

批准号：
10792362
负责人：
CATO T. LAURENCIN
金额：
$ 14.74万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10792362
关键词：
Musculoskeletal Regenerative engineering Tissues Training Programs

项目摘要

PROJECT SUMMARY / ABSTRACT We propose a novel NIAMS doctoral T32 Program, Regenerative Engineering of Musculoskeletal Tissues: A Convergence Doctoral Training Program, which offers inter-disciplinary research areas at the University of Connecticut (UConn) combining biomedical science and engineering faculties. Regenerative Engineering is defined as the Convergence of advanced materials science, stem cell science, physics, developmental biology and clinical translation for the regeneration of complex tissues and organ systems. The T32 Program will enroll 2 Ph.D. candidates per year and support each for 2 years of Graduate School. The students will be drawn from graduate programs at UConn (School of Medicine and School of Engineering). The students will then apply for T32 support at the end of Year 1 of graduate school to be supported for Years 2-3. They will all receive their Ph.D. from the Graduate School at UConn. The T32 Program will offer trainees a broad level of expertise in research and instruction based on the research, educational, and clinical experiences of the biomedical and engineering faculty who serve as preceptors. Trainees will become experts in regenerative engineering and its foundations to work towards the alleviation of human disease and musculoskeletal injuries by means of tissue regeneration. Musculoskeletal regeneration is a field ripe for an inventive approach based on convergence to address challenging issues, advance technology and further fundamental knowledge for therapeutic applications. At the center of the Convergence approach is the understanding that new solutions in regeneration will take place through an `un-siloed' approach. Thus, Regenerative Engineering welcomes ideas and research across a gamut of disciplines. The T32 Program has preceptorship commitments from 20 distinguished faculty at UConn (representing Biomedical Engineering, Cell Biology, Computer Science, Genetics and Genome Sciences, Materials Science, Mechanical Engineering, Molecular Biology and Biophysics, Oral Health, Orthopedic Surgery). This eminent group of investigators is well funded and published to provide the primary research training and serve as role models for doctoral trainees Our Program strengths include its interdisciplinary and collaborative research in biomedical science and engineering, interactions with diverse trainees and faculty, training in contemporary research methodologies, and successful preceptors. T32 Program administration through the Connecticut Convergence Institute for Translation in Regenerative Engineering will provide the experience to recruit diverse trainees, including minorities, implement the curriculum, and train a new cadre of convergence scientists.

项目摘要/摘要我们提出了一个新的NIAMS博士T32项目，肌肉骨骼组织的再生工程：汇聚博士培养计划，在大学提供跨学科研究领域康涅狄格大学(UConn)将生物医学科学和工程学院结合在一起。再生工程被定义为先进材料科学、干细胞科学、物理学、发展生物学和临床翻译，用于复杂组织和器官系统的再生。T32程序每年招收2名博士生，每人资助2年的研究生院学习。学生们将会来自康涅狄格州大学(医学院和工程学院)的研究生课程。学生们然后在研究生院第一年结束时申请T32支持，并支持第二到第三年。他们都将从康涅狄格州大学研究生院获得博士学位。T32计划将为学员提供广泛的基于研究、教育和临床经验的研究和教学专业水平作为导师的生物医学和工程学教员。学员将成为再生工程及其基金会致力于减轻人类疾病和通过组织再生的方式造成肌肉骨骼损伤。肌肉骨骼再生是一个成熟的领域以融合为基础的创造性方法，以解决具有挑战性的问题、推进技术和进一步治疗应用的基础知识。融合方法的核心是认识到再生方面的新解决办法将通过“非孤立”的办法来实现。因此，再生工程欢迎各种学科的想法和研究。T32程序有康涅狄格州大学20名杰出教员(代表生物医学)的授课承诺工程学、细胞生物学、计算机科学、遗传学和基因组科学、材料科学、机械工程、分子生物学和生物物理学、口腔健康、整形外科)。这位杰出的一组调查人员资金充足并出版，以提供初步的研究培训，并作为博士生的榜样我们的项目优势包括跨学科和协作性生物医学科学和工程研究，与不同的受训人员和教员互动，培训当代的研究方法和成功的导师。T32计划管理通过康涅狄格州再生工程翻译学院将提供经验招收包括少数民族在内的各类学员，落实课程设置，培养新干部趋同科学家。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults.

DOI：
10.3389/fragi.2023.1272336
发表时间：
2023
期刊：
FRONTIERS IN AGING
影响因子：
0
作者：
Martin, Dominique E.;Cadar, Andreia N.;Bartley, Jenna M.
通讯作者：
Bartley, Jenna M.

Pegylated insulin-like growth factor-1 biotherapeutic delivery promotes rotator cuff regeneration in a rat model.

DOI：
10.1002/jbm.a.37378
发表时间：
2022-07
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
影响因子：
4.9
作者：
Prabhath, Anupama;Vernekar, Varadraj N.;Esdaille, Caldon J.;Eisenberg, Ellen;Lebaschi, Amir;Badon, Mary;Seyedsalehi, Amir;Dzidotor, Godwin;Tang, Xiaoyan;Dyment, Nathaniel;Thomopoulos, Stavros;Kumbar, Sangamesh G.;Deymier, Alix;Weber, Eckhard;Laurencin, Cato T.
通讯作者：
Laurencin, Cato T.

Biodegradable Polyphosphazenes for Regenerative Engineering.