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Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training Program

肌肉骨骼组织再生工程-融合博士培训项目

基本信息

批准号：
10792362
负责人：
CATO T. LAURENCIN
金额：
$ 14.74万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10792362
关键词：
Musculoskeletal Regenerative engineering Tissues Training Programs

项目摘要

PROJECT SUMMARY / ABSTRACT We propose a novel NIAMS doctoral T32 Program, Regenerative Engineering of Musculoskeletal Tissues: A Convergence Doctoral Training Program, which offers inter-disciplinary research areas at the University of Connecticut (UConn) combining biomedical science and engineering faculties. Regenerative Engineering is defined as the Convergence of advanced materials science, stem cell science, physics, developmental biology and clinical translation for the regeneration of complex tissues and organ systems. The T32 Program will enroll 2 Ph.D. candidates per year and support each for 2 years of Graduate School. The students will be drawn from graduate programs at UConn (School of Medicine and School of Engineering). The students will then apply for T32 support at the end of Year 1 of graduate school to be supported for Years 2-3. They will all receive their Ph.D. from the Graduate School at UConn. The T32 Program will offer trainees a broad level of expertise in research and instruction based on the research, educational, and clinical experiences of the biomedical and engineering faculty who serve as preceptors. Trainees will become experts in regenerative engineering and its foundations to work towards the alleviation of human disease and musculoskeletal injuries by means of tissue regeneration. Musculoskeletal regeneration is a field ripe for an inventive approach based on convergence to address challenging issues, advance technology and further fundamental knowledge for therapeutic applications. At the center of the Convergence approach is the understanding that new solutions in regeneration will take place through an `un-siloed' approach. Thus, Regenerative Engineering welcomes ideas and research across a gamut of disciplines. The T32 Program has preceptorship commitments from 20 distinguished faculty at UConn (representing Biomedical Engineering, Cell Biology, Computer Science, Genetics and Genome Sciences, Materials Science, Mechanical Engineering, Molecular Biology and Biophysics, Oral Health, Orthopedic Surgery). This eminent group of investigators is well funded and published to provide the primary research training and serve as role models for doctoral trainees Our Program strengths include its interdisciplinary and collaborative research in biomedical science and engineering, interactions with diverse trainees and faculty, training in contemporary research methodologies, and successful preceptors. T32 Program administration through the Connecticut Convergence Institute for Translation in Regenerative Engineering will provide the experience to recruit diverse trainees, including minorities, implement the curriculum, and train a new cadre of convergence scientists.

项目总结/摘要我们提出了一个新的NIAMS博士T32计划，肌肉骨骼组织的再生工程：一个融合博士培训计划，提供跨学科的研究领域在大学康涅狄格大学（UConn）将生物医学科学和工程学院相结合。再生工程被定义为先进材料科学、干细胞科学、物理学、发展复杂组织和器官系统再生的生物学和临床翻译。T32计划将招收2名博士候选人每年和支持每个2年的研究生院。学生将从康州大学（医学院和工程学院）的研究生课程中抽取。学生然后将在研究生院第一年结束时申请T32支持，以支持第二年至第三年。他们都将获得博士学位来自康州大学研究生院T32计划将为学员提供广泛的基于研究，教育和临床经验的研究和教学专业知识水平生物医学和工程学院的导师。学员将成为专家，再生工程及其基础，致力于减轻人类疾病，通过组织再生治疗肌肉骨骼损伤。肌肉骨骼再生是一个成熟的领域，本发明方法基于解决挑战性问题、先进技术和进一步治疗应用的基础知识。融合方法的核心是认识到再生方面的新解决办法将通过一种“非孤立”的办法来实现。因此，在本发明中，再生工程欢迎跨学科的想法和研究。T32计划拥有来自康州大学20名杰出教师的导师承诺（代表生物医学工程学、细胞生物学、计算机科学、遗传学和基因组科学、材料科学、机械工程、分子生物学和生物物理学、口腔健康、整形外科）。这位杰出一组研究人员资金充足，出版，提供主要的研究培训，并作为博士生的榜样我们的计划优势包括其跨学科和协作生物医学科学与工程研究，与不同学员和教师的互动，当代研究方法和成功的导师。T32通过康涅狄格州再生工程翻译融合研究所将提供经验招募包括少数民族在内的各种学员，实施课程，并培训新的聚合科学家

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults.

DOI：
10.3389/fragi.2023.1272336
发表时间：
2023
期刊：
FRONTIERS IN AGING
影响因子：
0
作者：
Martin, Dominique E.;Cadar, Andreia N.;Bartley, Jenna M.
通讯作者：
Bartley, Jenna M.

Pegylated insulin-like growth factor-1 biotherapeutic delivery promotes rotator cuff regeneration in a rat model.

DOI：
10.1002/jbm.a.37378
发表时间：
2022-07
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
影响因子：
4.9
作者：
Prabhath, Anupama;Vernekar, Varadraj N.;Esdaille, Caldon J.;Eisenberg, Ellen;Lebaschi, Amir;Badon, Mary;Seyedsalehi, Amir;Dzidotor, Godwin;Tang, Xiaoyan;Dyment, Nathaniel;Thomopoulos, Stavros;Kumbar, Sangamesh G.;Deymier, Alix;Weber, Eckhard;Laurencin, Cato T.
通讯作者：
Laurencin, Cato T.

Biodegradable Polyphosphazenes for Regenerative Engineering.